Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

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Abstract

Clostridium difficile infection (CDI) is a major burden in health care and community settings. CDI recurrence is of particular concern because of limited treatment options and associated clinical and infection control issues. Fecal microbiota transplantation (FMT) is a promising, but not readily available, intervention.

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Journal

Journal ID (iso-abbrev): JAMA

Title: JAMA

ISSN (Electronic): 1538-3598

ISSN (Print): 0098-7484

Publication date (Electronic): Jan 12 2016

Volume: 315

Issue: 2

Affiliations

[1 ] Hamilton Regional Laboratory Medicine Program, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada2Department of Medicine, McMaster University, Hamilton, Ontario, Canada3St Joseph's Healthcare, Hamilton, Ontario, C.

[2 ] Division of Infectious Diseases and Immunity and Infection Research Centre, Vancouver Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

[3 ] Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

[4 ] Division of Medical Microbiology and Infection Control, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

[5 ] Centre for Public Health and Zoonoses, Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

[6 ] Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

[7 ] Department of Medicine, McMaster University, Hamilton, Ontario, Canada3St Joseph's Healthcare, Hamilton, Ontario, Canada.

[8 ] Hamilton Regional Laboratory Medicine Program, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada3St Joseph's Healthcare, Hamilton, Ontario, Canada.

[9 ] St Joseph's Healthcare, Hamilton, Ontario, Canada.

[10 ] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

[11 ] Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada12Halton Healthcare Services, Oakville, Ontario, Canada.

[12 ] Hamilton Regional Laboratory Medicine Program, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada10Department of Mathematics and Statistics, University of Guelph, Guelph, Ontario, Canada.

Article

Publisher Item ID: 2481003

DOI: 10.1001/jama.2015.18098

PubMed ID: 26757463

SO-VID: 00800888-7668-4be7-a37d-da650bf17233

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