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Physicochemical properties and antioxidant activity of α-tocopherol loaded nanoliposome’s containing DHA and EPA
January 2017
January 2017
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Abstract
The aim of this study was to prepare α-tocopherol loaded nanoliposomes as carriers
of DHA and EPA and to investigate their physicochemical properties, such as peroxide
value (PV), volatile compounds (VOCs), particle size, size distribution, zeta potential
and morphology of the liposomes. The particle size of liposomes was in the range of
82.4-107.2nm. The highest extent of lipid oxidation was observed at 40°C for 90days,
with the lowest PV and propanal levels for a nanoliposome formulation in comparison
with the control sample. The zeta potential of the nanoliposomes was decreased during
storage. No significant change in the PV and zeta potential of the liposome formulations
with α-tocopherol was observed at 4°C after 90days (0.14meq/kg and -43.5mV, respectively).
This study demonstrated that incorporation of α-tocopherol into liposomes contributes
a significant antioxidant effect on DHA and EPA.