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      Hepatokines and metabolism: Deciphering communication from the liver.

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          Abstract

          The liver is a key regulator of systemic energy homeostasis and can sense and respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation of systemic energy homeostasis by the liver is mediated in part through regulation of glucose and lipid metabolism. Dysregulation of either process may result in metabolic dysfunction and contribute to the development of insulin resistance or fatty liver disease.

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          Most cited references272

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          Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

          Emelia Benjamin, Paul Muntner, Alvaro Alonso … (2019)
          Circulation, 139(10)
          Article 0 comments Cited 2436 times – based on 0 reviews     Review now
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            MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

            Mohammed Eslam, Arun Sanyal, Jacob George (2020)
            Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. Although pharmacotherapies are in development, response rates appear modest. The heterogeneous pathogenesis of metabolic fatty liver diseases and inaccuracies in terminology and definitions necessitate a reappraisal of nomenclature to inform clinical trial design and drug development. A group of experts sought to integrate current understanding of patient heterogeneity captured under the acronym nonalcoholic fatty liver disease (NAFLD) and provide suggestions on terminology that more accurately reflects pathogenesis and can help in patient stratification for management. Experts reached consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term. This opens the door for efforts from the research community to update the nomenclature and subphenotype the disease to accelerate the translational path to new treatments.
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              Inflammation and metabolic disorders.

              Gökhan S. Hotamisligil (2006)
              Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.
              Article 0 comments Cited 1045 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Mol Metab
                Title: Molecular metabolism
                Publisher: Elsevier BV
                ISSN (Electronic): 2212-8778
                ISSN (Print): 2212-8778
                Publication date (Electronic): Feb 2021
                Volume: 44
                Affiliations
                [1 ] Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
                [2 ] Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address: matthew-potthoff@uiowa.edu.
                Article
                Publisher Item ID: S2212-8778(20)30212-X
                DOI: 10.1016/j.molmet.2020.101138
                PMC ID: 7788242
                PubMed ID: 33285302
                SO-VID: 6602bfd2-e92c-4c11-b92b-2f9d68f60de5
                Copyright © Published by Elsevier GmbH.
                History

                Keywords: Glucose homeostasis,Hepatokine,Insulin sensitivity,Liver,Nutrient,Obesity
                Data availability:
                Keywords: Glucose homeostasis, Hepatokine, Insulin sensitivity, Liver, Nutrient, Obesity

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