Omega-3 polyunsaturated fatty acid derived lipid mediators: a comprehensive update on their application in anti-cancer drug discovery.

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Abstract

ω-3 Polyunsaturated fatty acids (PUFAs) have a range of health benefits, including anticancer activity, and are converted to lipid mediators that could be adapted into pharmacological strategies. However, the stability of these mediators must be improved, and they may require formulation to achieve optimal tissue concentrations.

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Author and article information

Journal

Journal ID (iso-abbrev): Expert Opin Drug Discov

Title: Expert opinion on drug discovery

Publisher: Informa UK Limited

ISSN (Electronic): 1746-045X

ISSN (Print): 1746-0441

Publication date (Electronic): May 2024

Volume: 19

Issue: 5

Affiliations

[1 ] Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.

[2 ] Woolcock Institute of Medical Research, Macquarie University, Macquarie Park, NSW, Australia.

Article

DOI: 10.1080/17460441.2024.2340493

PubMed ID: 38595031

SO-VID: 816a2cc9-93f7-4531-a216-f4aa316a240f

History

Keywords: endoplasmic-reticulum stress,ω-3 17,18-epoxyeicosatetraenoic acid,protonophoric uncoupler,mitochondrial targeting,ω-3 polyunsaturated fatty acids,Bioisosteric replacement

Data availability:

Keywords: endoplasmic-reticulum stress, ω-3 17,18-epoxyeicosatetraenoic acid, protonophoric uncoupler, mitochondrial targeting, ω-3 polyunsaturated fatty acids, Bioisosteric replacement

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