Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.

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Abstract

Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in multiple sclerosis when measured with SD-OCT.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

Publisher: Elsevier BV

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Oct 2017

Volume: 16

Issue: 10

Affiliations

[1 ] Moorfields Eye Hospital, London, UK; Department of Neurology, Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Center, Amsterdam, Netherlands; Institute of Neurology, University College London, London, UK. Electronic address: a.petzold@ucl.ac.uk.

[2 ] Department of Neurology, Department of Ophthalmology, and Department of Population Health, New York University School of Medicine, New York, NY, USA.

[3 ] Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.

[4 ] Department of Clinical Neurosciences and Department of Surgery, University of Calgary, Calgary, AB, Canada.

[5 ] Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

[6 ] Center of Neuroimmunology, Institute of Biomedical Research August Pi Sunyer, Hospital Clinic of Barcelona, Barcelona, Spain.

[7 ] Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

[8 ] Iowa City VA Center for Prevention and Treatment of Visual Loss, Department of Veterans Affairs Hospital Iowa City, and Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, IA, USA.

[9 ] Department of Neurology, University of Lille Nord de France, Lille, France.

[10 ] NeuroCure Clinical Research Center, Charité, Department of Neurology, Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Berlin, Germany.

[11 ] Neuroimmunology and Multiple Sclerosis Research Section, University Hospital Zurich, Zurich, Switzerland.

[12 ] Université Lille, CHRU Lille, LYRIC-INSERM U995, FHU Imminent, Lille, France.

[13 ] Department of Neurology, Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Center, Amsterdam, Netherlands.

Article

Publisher Item ID: S1474-4422(17)30278-8

DOI: 10.1016/S1474-4422(17)30278-8

PubMed ID: 28920886

SO-VID: c92def27-1833-4ce4-8496-418b5be4b3b5

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