Measurement of longitudinal β-amyloid change with 18F-florbetapir PET and standardized uptake value ratios.

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Abstract

The accurate measurement of β-amyloid (Aβ) change using amyloid PET imaging is important for Alzheimer disease research and clinical trials but poses several unique challenges. In particular, reference region measurement instability may lead to spurious changes in cortical regions of interest. To optimize our ability to measure (18)F-florbetapir longitudinal change, we evaluated several candidate regions of interest and their influence on cortical florbetapir change over a 2-y period in participants from the Alzheimer Disease Neuroimaging Initiative (ADNI).

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Journal

Journal ID (iso-abbrev): J. Nucl. Med.

Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

ISSN (Electronic): 1535-5667

ISSN (Print): 0161-5505

Publication date (Electronic): Apr 2015

Volume: 56

Issue: 4

Affiliations

[1 ] Helen Wills Neuroscience Institute, University of California, Berkeley, California Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California slandau@berkeley.edu.

[2 ] Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

[3 ] Radiology Department, University of Michigan, Ann Arbor, Michigan.

[4 ] Avid Radiopharmaceuticals, Inc., Philadelphia, Pennsylvania; and.

[5 ] Banner Alzheimer's Institute, Phoenix, Arizona.

[6 ] Helen Wills Neuroscience Institute, University of California, Berkeley, California Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

Article

Publisher Item ID: jnumed.114.148981

DOI: 10.2967/jnumed.114.148981

PubMed ID: 25745095

SO-VID: e5b098da-1377-4070-9207-4d5c41790738

History

Keywords: Alzheimer’s disease,PET imaging,amyloid

Data availability:

Keywords: Alzheimer’s disease, PET imaging, amyloid

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