For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
42
references
 Top references
cited by
13
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      696
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Association Between Brain Substructure Dose and Cognitive Outcomes in Children With Medulloblastoma Treated on SJMB03: A Step Toward Substructure-Informed Planning.

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To characterize the association between neurocognitive outcomes (memory and processing speed) and radiation (RT) dose to the hippocampus, corpus callosum (CC), and frontal white matter (WM) in children with medulloblastoma treated on a prospective study, SJMB03.

          Related collections

          Most cited references42

          • Record: found
          • Abstract: found
          • Article: found

          DNA methylation-based classification of central nervous system tumours

          David Capper, David Jones, Martin Sill … (2018)
          Summary Accurate pathological diagnosis is crucial for optimal management of cancer patients. For the ~100 known central nervous system (CNS) tumour entities, standardization of the diagnostic process has been shown to be particularly challenging - with substantial inter-observer variability in the histopathological diagnosis of many tumour types. We herein present the development of a comprehensive approach for DNA methylation-based CNS tumour classification across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that availability of this method may have substantial impact on diagnostic precision compared with standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility we have designed a free online classifier tool (www.molecularneuropathology.org) requiring no additional onsite data processing. Our results provide a blueprint for the generation of machine learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
          Article 0 comments Cited 799 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Neurogenesis in the adult human hippocampus.

            P. Eriksson, E Perfilieva, T Björk-Eriksson … (1998)
            The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, in regions previously identified as neurogenic in adult rodents and monkeys. Human brain tissue was obtained postmortem from patients who had been treated with the thymidine analog, bromodeoxyuridine (BrdU), that labels DNA during the S phase. Using immunofluorescent labeling for BrdU and for one of the neuronal markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans. Our results further indicate that the human hippocampus retains its ability to generate neurons throughout life.
            Article 0 comments Cited 423 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The cognitive neuroscience of working memory.

              Mark D'Esposito, Bradley R. Postle (2015)
              For more than 50 years, psychologists and neuroscientists have recognized the importance of a working memory to coordinate processing when multiple goals are active and to guide behavior with information that is not present in the immediate environment. In recent years, psychological theory and cognitive neuroscience data have converged on the idea that information is encoded into working memory by allocating attention to internal representations, whether semantic long-term memory (e.g., letters, digits, words), sensory, or motoric. Thus, information-based multivariate analyses of human functional MRI data typically find evidence for the temporary representation of stimuli in regions that also process this information in nonworking memory contexts. The prefrontal cortex (PFC), on the other hand, exerts control over behavior by biasing the salience of mnemonic representations and adjudicating among competing, context-dependent rules. The "control of the controller" emerges from a complex interplay between PFC and striatal circuits and ascending dopaminergic neuromodulatory signals.
              Article 0 comments Cited 400 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (iso-abbrev): J Clin Oncol
                Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
                Publisher: American Society of Clinical Oncology (ASCO)
                ISSN (Electronic): 1527-7755
                ISSN (Print): 0732-183X
                Publication date (Electronic): January 01 2022
                Volume: 40
                Issue: 1
                Affiliations
                [1 ] Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN.
                [2 ] Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD.
                [3 ] Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN.
                [4 ] Department of Psychology, St Jude Children's Research Hospital, Memphis, TN.
                [5 ] Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN.
                [6 ] Division of Neuro-Oncology, St Jude Children's Research Hospital, Memphis, TN.
                Article
                DOI: 10.1200/JCO.21.01480
                PMC ID: 8683226
                PubMed ID: 34714708
                SO-VID: 6672cc88-5b2d-4bab-9f61-3f7c882d154a
                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content696

                See all similar

                Cited by13

                See all cited by