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Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement.
Panisadee Avirutnan
1 ,
Nuntaya Punyadee ,
Sansanee Noisakran ,
Chulaluk Komoltri ,
Somchai Thiemmeca ,
Kusuma Auethavornanan ,
Aroonroong Jairungsri ,
Rattiyaporn Kanlaya ,
Nattaya Tangthawornchaikul ,
Chunya Puttikhunt ,
Sa-Nga Pattanakitsakul ,
Pa-Thai Yenchitsomanus ,
Juthathip Mongkolsapaya ,
Watchara Kasinrerk ,
Nopporn Sittisombut ,
Matthias Husmann ,
Maria Blettner ,
Sirijitt Vasanawathana ,
Sucharit Bhakdi ,
Prida Malasit
Apr 15 2006
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Abstract
Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown.