Eosinophilic Esophagitis-Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior.

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Abstract

Eosinophilic esophagitis (EoE) is an immune-mediated allergic disease characterized by progressive esophageal dysmotility and fibrotic stricture associated with chronic esophageal fibroblast activation. It remains unknown how esophageal fibroblasts respond to EoE-relevant matrix stiffness or inflammatory cytokines.

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Journal

Journal ID (iso-abbrev): J. Pediatr. Gastroenterol. Nutr.

Title: Journal of pediatric gastroenterology and nutrition

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1536-4801

ISSN (Print): 0277-2116

Publication date (Electronic): Aug 2016

Volume: 63

Issue: 2

Affiliations

[1 ] *Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, PA †Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania ‡Department of Bioengineering, University of Pennsylvania §University of Pennsylvania School of Engineering and Applied Science, Philadelphia ||Division of Gastroenterology, Seattle Children's Hospital ¶Gastroenterology Division, Department of Medicine #Abramson Cancer Center, University of Pennsylvania, Philadelphia **Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.

Article

Mid ID: NIHMS747644

DOI: 10.1097/MPG.0000000000001100

PMC ID: 4929044

PubMed ID: 26727658

SO-VID: 0f6b4636-4c1d-4fe8-a9b8-a16f543b44a9

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