Two hypotheses derived from a theory of perceived social support were investigated: (a) relationship-based perceptions of social support are distinct from general perceptions of support, and (b) measures of each construct contribute uniquely to the prediction of loneliness. Ninety-four male and 116 female undergraduates completed measures of loneliness and general perceived social support and the Quality of Relationships Inventory, a new instrument to assess relationship-based perceptions of social support, conflict, and depth in specific relationships. General and relationship-based perceptions of social support were found to be related, but empirically distinct, constructs. Relationship-based perceptions of support and conflict from mothers and friends each added to the prediction of loneliness after considering the contribution of general perceived social support. Implications of these findings for understanding the perceived social support construct are discussed.