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Prediction of Creatinine Clearance from Serum Creatinine
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Abstract
A formula has been developed to predict creatinine clearance (C<sub>cr</sub>) from
serum creatinine (S<sub>cr</sub>) in adult males: Ccr = (140 – age) (wt kg)/72 × S<sub>cr</sub>(mg/100ml)
(15% less in females). Derivation included the relationship found between age and
24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for C<sub>cr</sub>
were predicted by this formula and four other methods and the results compared with
the means of two 24-hour C<sub>cr’s</sub> measured in 236 patients. The above formula
gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83;
on average, the difference between predicted and mean measured values was no greater
than that between paired clearances. Factors for age and body weight must be included
for reasonable prediction.