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      Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: a population-based study of diagnoses and risk factors

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          Abstract

          Background

          Eating disorders (EDs) are common amongst women; however, no research has specifically investigated the lifetime/12-month prevalence of eating disorders amongst women in mid-life (i.e., fourth and fifth decade of life) and the relevant longitudinal risk factors. We aimed to investigate the lifetime and 12-month prevalence of EDs and lifetime health service use and to identify childhood, parenting, and personality risk factors.

          Methods

          This is a two-phase prevalence study, nested within an existing longitudinal community-based sample of women in mid-life. A total of 5658 women from the UK Avon Longitudinal Study of Parents and Children (ALSPAC; enrolled 20 years earlier) participated. ED diagnoses were obtained using validated structured interviews. Weighted analyses were carried out accounting for the two-phase methodology to obtain prevalence figures and to carry out risk factor regression analyses.

          Results

          By mid-life, 15.3% (95% confidence intervals, 13.5–17.4%) of women had met criteria for a lifetime ED. The 12-month prevalence of EDs was 3.6%. Childhood sexual abuse was prospectively associated with all binge/purge type disorders and an external locus of control was associated with binge-eating disorder. Better maternal care was protective for bulimia nervosa. Childhood life events and interpersonal sensitivity were associated with all EDs.

          Conclusions

          By mid-life a significant proportion of women will experience an ED, and few women accessed healthcare. Active EDs are common in mid-life, both due to new onset and chronic disorders. Increased awareness of the full spectrum of EDs in this stage of life and adequate service provision is important. This is the first study to investigate childhood and personality risk factors for full threshold and sub-threshold EDs and to identify common predictors for full and sub-threshold EDs. Further research should clarify the role of preventable risk factors on both full and sub-threshold EDs.

          Electronic supplementary material

          The online version of this article (doi:10.1186/s12916-016-0766-4) contains supplementary material, which is available to authorized users.

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          Most cited references53

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          Diagnostic and Statistical Manual of Mental Disorders

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            Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

            The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enrol pregnant women in the Bristol area of the UK during 1990–92; this was extended to include additional children eligible using the original enrolment definition up to the age of 18 years. The children from 14 541 pregnancies were recruited in 1990–92, increasing to 15 247 pregnancies by the age of 18 years. This cohort profile describes the index children of these pregnancies. Follow-up includes 59 questionnaires (4 weeks–18 years of age) and 9 clinical assessment visits (7–17 years of age). The resource comprises a wide range of phenotypic and environmental measures in addition to biological samples, genetic (DNA on 11 343 children, genome-wide data on 8365 children, complete genome sequencing on 2000 children) and epigenetic (methylation sampling on 1000 children) information and linkage to health and administrative records. Data access is described in this article and is currently set up as a supported access resource. To date, over 700 peer-reviewed articles have been published using ALSPAC data.
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              Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

              Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19–22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17–18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.
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                Author and article information

                Contributors
                n.micali@mssm.edu
                m.martini@ucl.ac.uk
                jjthomas@mgh.harvard.edu
                keddy@mgh.harvard.edu
                r.kothari@ucl.ac.uk
                ellie_russell@yahoo.co.uk
                cbulik@med.unc.edu
                janet.treasure@kcl.ac.uk
                Journal
                BMC Med
                BMC Med
                BMC Medicine
                BioMed Central (London )
                1741-7015
                17 January 2017
                17 January 2017
                2017
                : 15
                : 12
                Affiliations
                [1 ]Eating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY USA
                [2 ]Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA
                [3 ]Institute of Child Health, University College London, London, UK
                [4 ]Department of Psychiatry, Harvard Medical School, Boston, MA USA
                [5 ]Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA USA
                [6 ]Department of Psychological Medicine, Cardiff University, Cardiff, UK
                [7 ]Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA
                [8 ]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
                [9 ]Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC USA
                [10 ]Eating Disorders Research Unit, Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK
                Article
                766
                10.1186/s12916-016-0766-4
                5240354
                28095833
                fa40bdb0-8695-41df-9999-80a94f048f6d
                © The Author(s). 2017

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 19 August 2016
                : 26 November 2016
                Funding
                Funded by: National Institute of health Research (NIHR)
                Award ID: DHCS/08/08/012
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100008173, Wellchild;
                Award ID: n/a
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/100004440, Wellcome Trust;
                Award ID: 092731
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2017

                Medicine
                eating disorders,anorexia nervosa,bulimia nervosa,binge eating disorder,alspac,women,mid-life,prevalence,risk factors,childhood

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