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Validation of the Erlangen Score Algorithm for the Prediction of the Development of Dementia due to Alzheimer's Disease in Pre-Dementia Subjects.
Piotr Lewczuk
1 ,
Johannes Kornhuber
1 ,
Jon B Toledo
2 ,
John Q Trojanowski
2 ,
Malgorzata Knapik-Czajka
2 ,
Oliver Peters
3 ,
Jens Wiltfang
4 ,
Leslie M Shaw
2
2015
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Abstract
In previous studies, a dichotomous stratification of subjects into "cerebrospinal fluid (CSF) normal" and "CSF pathologic" was used to investigate the role of biomarkers in the prediction of progression to dementia in pre-dementia/mild cognitive impairment subjects. With the previously published Erlangen Score Algorithm, we suggested a division of CSF patterns into five groups, covering all possible CSF result combinations based on the presence of pathologic tau and/or amyloid-β CSF values.