Clinical characteristics of patients with spondyloarthritis and inflammatory bowel disease versus inflammatory bowel disease-related arthritis.

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Abstract

The purpose of this study was to clarify the clinical characteristics of spondyloarthritis (SpA) patients with inflammatory bowel disease (IBD) compared to those without IBD. Furthermore, among patients with SpA and IBD, we aimed to clarify what clinical characteristics lead rheumatologists to diagnose "IBD-related arthritis." Utilizing SpA and psoriatic arthritis (PsA) patients' data from an international, cross-sectional, observational study, we analyzed information on demographics and disease characteristics, dichotomizing patients by IBD status. The presence or absence of IBD was determined based on data collection of treating rheumatologists. Patients with SpA (including PsA) and IBD were also categorized based on treating rheumatologists' definitive diagnosis in regard to SpA type, and compared by whether the patients had IBD-related arthritis or not. Among 4465 SpA patients, 287 (6.4%, 95%CI 5.7-7.2%) were identified with IBD. Compared to SpA patients without IBD, patients with SpA and IBD had a longer diagnostic delay (5.1 vs. 2.9 years, p < 0.001). In patients with SpA and IBD, 111 (38.7%, 95%CI 33.0-44.6%) were diagnosed with IBD-related arthritis. Multivariable analyses showed that HLA-B27 positivity [OR = 0.35, (95%CI 0.15-0.80)], psoriasis [OR = 0.14, (95%CI 0.04-0.50)], IBD as first symptom of SpA [OR = 3.32, (95%CI 1.84-6.01)], and need for IBD-specific treatment [OR = 5.41, (95%CI 2.02-14.50)] were independently associated with the definitive diagnosis of IBD-related arthritis. Collaboration with gastroenterologists is needed to shorten the diagnostic delay in patients with SpA and IBD. The recognition of the factors for the diagnosis of "IBD-related arthritis" may lead to the elucidation of the pathogenesis.

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Investigation of the freely available easy-to-use software ‘EZR' for medical statistics

Y Kanda (2012)

Although there are many commercially available statistical software packages, only a few implement a competing risk analysis or a proportional hazards regression model with time-dependent covariates, which are necessary in studies on hematopoietic SCT. In addition, most packages are not clinician friendly, as they require that commands be written based on statistical languages. This report describes the statistical software ‘EZR' (Easy R), which is based on R and R commander. EZR enables the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates, receiver operating characteristics analyses, meta-analyses, sample size calculation and so on, by point-and-click access. EZR is freely available on our website (http://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmed.html) and runs on both Windows (Microsoft Corporation, USA) and Mac OS X (Apple, USA). This report provides instructions for the installation and operation of EZR.

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Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.

Siew C. Ng, Hai Yun Shi, Nima Hamidi … (2017)

Inflammatory bowel disease is a global disease in the 21st century. We aimed to assess the changing incidence and prevalence of inflammatory bowel disease around the world.

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The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection.

M Rudwaleit, D van der Heijde, R Landewé … (2009)

To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). All Assessment of SpondyloArthritis international Society (ASAS) members were invited to include consecutively new patients with chronic (> or =3 months) back pain of unknown origin that began before 45 years of age. The candidate criteria were first tested in the entire cohort of 649 patients from 25 centres, and then refined in a random selection of 40% of cases and thereafter validated in the remaining 60%. Upon diagnostic work-up, axial SpA was diagnosed in 60.2% of the cohort. Of these, 70% did not fulfil modified New York criteria and, therefore, were classified as having "non-radiographic" axial SpA. Refinement of the candidate criteria resulted in new ASAS classification criteria that are defined as: the presence of sacroiliitis by radiography or by magnetic resonance imaging (MRI) plus at least one SpA feature ("imaging arm") or the presence of HLA-B27 plus at least two SpA features ("clinical arm"). The sensitivity and specificity of the entire set of the new criteria were 82.9% and 84.4%, and for the imaging arm alone 66.2% and 97.3%, respectively. The specificity of the new criteria was much better than that of the European Spondylarthropathy Study Group criteria modified for MRI (sensitivity 85.1%, specificity 65.1%) and slightly better than that of the modified Amor criteria (sensitivity 82.9, specificity 77.5%). The new ASAS classification criteria for axial SpA can reliably classify patients for clinical studies and may help rheumatologists in clinical practice in diagnosing axial SpA in those with chronic back pain. NCT00328068.

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Journal

Journal ID (iso-abbrev): Rheumatol Int

Title: Rheumatology international

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1437-160X

ISSN (Print): 0172-8172

Publication date (Electronic): Oct 2022

Volume: 42

Issue: 10

Affiliations

[1 ] Department of Nephrology and Rheumatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181-8611, Japan.

[2 ] Department of Nephrology and Rheumatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181-8611, Japan. kishimotomi@gmail.com.

[3 ] Department of General Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.

[4 ] Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan.

[5 ] Center for Clinical Epidemiology, St. Luke's International University, Tokyo, Japan.

[6 ] Department of Medicine, University of Hawaii, Honolulu, HI, USA.

[7 ] Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.

[8 ] Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.

[9 ] Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

[10 ] Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi, Japan.

[11 ] Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.

[12 ] Department of Orthopedic Surgery, Nippon Life Hospital, Osaka, Japan.

[13 ] Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

[14 ] Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

[15 ] Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

[16 ] Department of Rheumatology, Daido Hospital, Aichi, Japan.

[17 ] Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

[18 ] Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France.

[19 ] Department of Rheumatology, Sofia University Hospital, IMIBIC, University of Cordoba, ReinaCordoba, Spain.

[20 ] Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan.

Article

Publisher Item ID: 10.1007/s00296-022-05117-0

DOI: 10.1007/s00296-022-05117-0

PubMed ID: 35532790

SO-VID: e882bae2-c938-45c6-a028-4a5c44c88c9d

History

Keywords: Psoriatic arthritis,Inflammatory bowel disease,Inflammatory bowel disease-related arthritis,Spondyloarthritis

Data availability:

Keywords: Psoriatic arthritis, Inflammatory bowel disease, Inflammatory bowel disease-related arthritis, Spondyloarthritis

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Clinical characteristics of patients with spondyloarthritis and inflammatory bowel disease versus inflammatory bowel disease-related arthritis.

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Most cited references 39

Investigation of the freely available easy-to-use software ‘EZR' for medical statistics

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection.

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