Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial.

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Abstract

The clinical benefit of preventive eradication of unruptured brain arteriovenous malformations remains uncertain. A Randomised trial of Unruptured Brain Arteriovenous malformations (ARUBA) aims to compare the risk of death and symptomatic stroke in patients with an unruptured brain arteriovenous malformation who are allocated to either medical management alone or medical management with interventional therapy.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Feb 15 2014

Volume: 383

Issue: 9917

Affiliations

[1 ] The Neurological Institute, Columbia University Medical Center, New York, NY, USA.

[2 ] International Center for Health Outcomes and Innovation Research, Department of Health Evidence and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

[3 ] The Neurological Institute, Columbia University Medical Center, New York, NY, USA; Department of Neurology, APHP-Hôpital Lariboisière, Univ Paris Diderot-Sorbonne Paris Cité, Paris, France; DHU NeuroVasc, APHP-Hôpital Lariboisière, Univ Paris Diderot-Sorbonne Paris Cité, Paris, France. Electronic address: christian.stapf@lrb.aphp.fr.

[4 ] National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

[5 ] Division of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

[6 ] Unité de Recherche Clinique, APHP-Hôpital Lariboisière, Univ Paris Diderot-Sorbonne Paris Cité, Paris, France.

[7 ] Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.

[8 ] Department of Neuroradiology, APHP-Hôpital Lariboisière, Univ Paris Diderot-Sorbonne Paris Cité, Paris, France.

[9 ] Department of Neurology, CHRU Lille, Université Lille Nord de France, Lille, France.

[10 ] Department of Neurology and Neurosurgery, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.

[11 ] Charité-Universitätsmedizin Berlin Berlin, Germany; Department of Neurology, Klinikum Frankfurt/Oder, Frankfurt/Oder Oder, Germany.

[12 ] Department of Neuroradiology, University Hospital Dresden, Dresden, Germany.

[13 ] Department of Neuroradiology and Endovascular Therapy, Jean Minjoz Hospital, University of Franche Comté, Besançon, France.

[14 ] Department of Neuroradiology, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany.

[15 ] Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, Netherlands.

[16 ] Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.

[17 ] Department of Neurology, North Shore Long Island Jewish Medical Center, New Hyde Park, NY, USA.

[18 ] Department of Diagnostic and Interventional Neuroimaging, CHU Pellegrin, Bordeaux, France.

Article

Publisher Item ID: S0140-6736(13)62302-8 Mid ID: NIHMS585104

DOI: 10.1016/S0140-6736(13)62302-8

PubMed ID: 24268105

SO-VID: 208e6c25-cad8-4647-8ea3-18a61349cc54

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