Retention in care outcomes for HIV pre-exposure prophylaxis implementation programmes among men who have sex with men in three US cities.

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Abstract

Despite the efficacy of pre-exposure prophylaxis (PrEP) in preventing HIV transmission, few studies have evaluated PrEP use and retention in care outcomes in real-world settings outside of clinical trials.

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Most cited references 36

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Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

Robert M Grant, Javier R Lama, Peter L Anderson … (2010)

Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition. We randomly assigned 2499 HIV-seronegative men or transgender women who have sex with men to receive a combination of two oral antiretroviral drugs, emtricitabine and tenofovir disoproxil fumarate (FTC-TDF), or placebo once daily. All subjects received HIV testing, risk-reduction counseling, condoms, and management of sexually transmitted infections. The study subjects were followed for 3324 person-years (median, 1.2 years; maximum, 2.8 years). Of these subjects, 10 were found to have been infected with HIV at enrollment, and 100 became infected during follow-up (36 in the FTC-TDF group and 64 in the placebo group), indicating a 44% reduction in the incidence of HIV (95% confidence interval, 15 to 63; P=0.005). In the FTC-TDF group, the study drug was detected in 22 of 43 of seronegative subjects (51%) and in 3 of 34 HIV-infected subjects (9%) (P<0.001). Nausea was reported more frequently during the first 4 weeks in the FTC-TDF group than in the placebo group (P<0.001). The two groups had similar rates of serious adverse events (P=0.57). Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects. Detectable blood levels strongly correlated with the prophylactic effect. (Funded by the National Institutes of Health and the Bill and Melinda Gates Foundation; ClinicalTrials.gov number, NCT00458393.).

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Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

Jared M. Baeten, Deborah Donnell, Patrick Ndase … (2012)

New England Journal of Medicine, 367(5), 399-410

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On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.

Jean-Michel Molina, Catherine Capitant, Bruno Spire … (2015)

Antiretroviral preexposure prophylaxis has been shown to reduce the risk of human immunodeficiency virus type 1 (HIV-1) infection in some studies, but conflicting results have been reported among studies, probably due to challenges of adherence to a daily regimen.

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Author and article information

Journal

Journal ID (iso-abbrev): J Int AIDS Soc

Title: Journal of the International AIDS Society

ISSN (Electronic): 1758-2652

ISSN (Print): 1758-2652

Publication date (Electronic): 2016

Volume: 19

Issue: 1

Affiliations

[1 ] Division of Infectious Diseases, The Miriam Hospital, Brown University, Providence, RI, USA; pchan@lifespan.org.

[2 ] Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA.

[3 ] Division of Infectious Diseases, Washington University in St. Louis, St. Louis, MO, USA.

[4 ] Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

[5 ] Department of Sociomedical Sciences, Columbia University, New York, NY, USA.

[6 ] Department of Social Work, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.

[7 ] The Fenway Institute, Fenway Health, Boston, MA, USA.

[8 ] Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

[9 ] Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA.

[10 ] Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.

[11 ] Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.

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Publisher Item ID: 20903

PMC ID: 4908080

PubMed ID: 27302837

SO-VID: 85f481fd-de6c-4167-a346-d20c25852da3

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Keywords: HIV,implementation,men who have sex with men,pre-exposure prophylaxis

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Keywords: HIV, implementation, men who have sex with men, pre-exposure prophylaxis

Retention in care outcomes for HIV pre-exposure prophylaxis implementation programmes among men who have sex with men in three US cities.

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Abstract

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Sex and gender-sensitive medicine

Most cited references 36

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.

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