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      Exercise Promotes Healthy Aging of Skeletal Muscle

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          Abstract

          Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics, and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes “healthy aging” by inducing modifications in skeletal muscle.

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          A new initiative on precision medicine.

          Francis Collins, Harold E. Varmus (2015)
          President Obama has announced a research initiative that aims to accelerate progress toward a new era of precision medicine, with a near-term focus on cancers and a longer-term aim to generate knowledge applicable to the whole range of health and disease.
          Article 0 comments Cited 669 times – based on 0 reviews     Review now
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            The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

            B Goodpaster, S. Park, T Harris … (2006)
            The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking.
            Article 0 comments Cited 432 times – based on 0 reviews     Review now
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              Sarcopenia: origins and clinical relevance.

              Irwin H. Rosenberg (1997)
              This presentation reflects on the origins of the term sarcopenia. The Greek roots of the word are sarx for flesh and penia for loss. The term actually describes important changes in body composition and related functions. Clearly defining sarcopenia will allow investigators to appropriately classify patients and examine underlying pathogenic mechanisms and will allow funding agencies to appropriately target research funds to a taxonomically distinct syndrome.
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                Author and article information

                Journal
                Journal ID (nlm-journal-id): 101233170
                Journal ID (pubmed-jr-id): 32527
                Journal ID (nlm-ta): Cell Metab
                Journal ID (iso-abbrev): Cell Metab.
                Title: Cell metabolism
                ISSN (Print): 1550-4131
                ISSN (Electronic): 1932-7420
                Publication date Nihms-submitted: 16 September 2016
                Publication date (Print): 14 June 2016
                Publication date PMC-release: 14 June 2017
                Volume: 23
                Issue: 6
                Pages: 1034-1047
                Affiliations
                [1 ]Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA
                [2 ]Department of Kinesiology, Centre for Translational Biology, McGill University Health Center, Canada; Meakins Christie Laboratories, Canada; Department of Medicine, McGill University, Canada
                [3 ]Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
                [4 ]Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden and Section of Integrative Physiology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
                Article
                Accession ID: PMC5045036 Pmcid ID: PMC5045036 Pmc-uid ID: 5045036 Manuscript ID: nihpa814819
                DOI: 10.1016/j.cmet.2016.05.007
                PMC ID: 5045036
                PubMed ID: 27304505
                SO-VID: 7250d958-d780-41ec-8f33-3a3f17e693ae
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