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Piezo1 (Piezo-Type Mechanosensitive Ion Channel Component 1)-Mediated Mechanosensation in Macrophages Impairs Perfusion Recovery After Hindlimb Ischemia in Mice.
Lan Xie
1 ,
Xiying Wang
1 ,
Yuankun Ma
1 ,
Hong Ma
1 ,
Jian Shen
1 ,
Jinyong Chen
1 ,
Yidong Wang
1 ,
Sheng'an Su
1 ,
Kaijie Chen
1 ,
Lingxiao Xu
1 ,
Yao Xie
1 ,
Meixiang Xiang
1
Apr 2023
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Abstract
Angiogenesis is a promising strategy for those with peripheral artery disease. Macrophage-centered inflammation is intended to govern the deficiency of the angiogenic response after hindlimb ischemia. However, little is known about the mechanism of macrophage activation beyond signals from cytokines and chemokines. We sought to identify a novel mechanical signal from the ischemic microenvironment that provokes macrophages and the subsequent inflammatory cascade and to investigate the potential role of Piezo-type mechanosensitive ion channels (Piezo) on macrophages during this process.