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Indinavir concentrations and St John's wort.

Author(s): S Piscitelli, D Chaitt, Fermín M. Alfaro, J Falloon, A L Burstein

Publication date: 2000-02-12

Journal: Lancet

Keywords: Administration, Oral, Adult, Area Under Curve, Chromatography, High Pressure Liquid, Drug Resistance, Female, HIV Protease Inhibitors, administration & dosage, antagonists & inhibitors, pharmacokinetics, Humans, Hypericum, adverse effects, Indinavir, Male, Middle Aged, Plants, Medicinal, Treatment Failure

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Abstract

St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.

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PubMed ID:: 10683007

DOI:: 10.1016/S0140-6736(99)05712-8

ScienceOpen disciplines: Chemistry

Keywords: Administration, Oral,Adult,Area Under Curve,Chromatography, High Pressure Liquid,Drug Resistance,Female,HIV Protease Inhibitors,administration & dosage,antagonists & inhibitors,pharmacokinetics,Humans,Hypericum,adverse effects,Indinavir,Male,Middle Aged,Plants, Medicinal,Treatment Failure

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ScienceOpen disciplines: Chemistry

Indinavir concentrations and St John's wort.

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