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      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis

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          Abstract

          Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for PPP. We report a patient with PPP improved by vedolizumab (anti-α4β7 integrin antibody) treatment for ulcerative colitis, suggesting the possibility of a new molecular target for PPP therapy.

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          Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

          Cezmi Akdis (2021)
          There has been a steep increase in allergic and autoimmune diseases, reaching epidemic proportions and now affecting more than one billion people worldwide. These diseases are more common in industrialized countries, and their prevalence continues to rise in developing countries in parallel to urbanization and industrialization. Intact skin and mucosal barriers are crucial for the maintenance of tissue homeostasis as they protect host tissues from infections, environmental toxins, pollutants and allergens. A defective epithelial barrier has been demonstrated in allergic and autoimmune conditions such as asthma, atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, coeliac disease and inflammatory bowel disease. In addition, leakiness of the gut epithelium is also implicated in systemic autoimmune and metabolic conditions such as diabetes, obesity, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and autoimmune hepatitis. Finally, distant inflammatory responses due to a 'leaky gut' and microbiome changes are suspected in Alzheimer disease, Parkinson disease, chronic depression and autism spectrum disorders. This article introduces an extended 'epithelial barrier hypothesis', which proposes that the increase in epithelial barrier-damaging agents linked to industrialization, urbanization and modern life underlies the rise in allergic, autoimmune and other chronic conditions. Furthermore, it discusses how the immune responses to dysbiotic microbiota that cross the damaged barrier may be involved in the development of these diseases.
          Article 0 comments Cited 254 times – based on 0 reviews     Review now
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            Paradoxical inflammation induced by anti-TNF agents in patients with IBD.

            Isabelle Cleynen, Séverine Vermeire (2012)
            Anti-TNF antibodies have acquired a prominent place in the management of IBD (including Crohn's disease and ulcerative colitis), rheumatologic conditions (such as rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis) and psoriasis. They have a good safety profile, especially when contraindications such as demyelinating disease, active infections and/or abscesses are ruled out, and when necessary precautions to prevent reactivation of tuberculosis are taken. However, with increasing use of these agents, paradoxical adverse events have been reported. Some of these features are shared with the underlying disease for which these drugs are given, making management of these conditions challenging. For example, anti-TNF therapy is used for the treatment of psoriasis, but psoriasiform lesions are sometimes observed in patients receiving therapy. Similarly, anti-TNF therapy is used for the treatment of rheumatologic diseases, but arthralgias and arthritis are sometimes observed in patients receiving anti-TNF agents. We review the paradoxical inflammation induced by anti-TNF agents in patients with IBD, provide hypotheses for the occurrence of this paradoxical inflammation and give practical advice on how to manage these patients.
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              Efficacy and Safety of Guselkumab, an Anti–interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis

              Keiichiro Hirose, Tadashi Terui, Satomi Kobayashi … (2018)
              Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated.
              Article 0 comments Cited 41 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Case Rep Dermatol
                Journal ID (iso-abbrev): Case Rep Dermatol
                Journal ID (hwp): CDE
                Journal ID (publisher-id): CDE
                Title: Case Reports in Dermatology
                Publisher: S. Karger AG (Basel, Switzerland )
                ISSN (Electronic): 1662-6567
                Publication date (Electronic): 27 January 2023
                Publication date Collection: Jan-Apr 2023
                Publication date PMC-release: 27 January 2023
                Volume: 15
                Issue: 1
                Pages: 22-25
                Affiliations
                [a ]Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
                [b ]Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
                Author notes
                Correspondence to: Hitoshi Terui hitoshiterui@ 123456derma.med.tohoku.ac.jp
                Article
                Publisher ID: 529080
                DOI: 10.1159/000529080
                PMC ID: 9885181
                SO-VID: d1bf86aa-6436-401a-b857-516c8e9aa586
                Copyright © © 2023 The Author(s). Published by S. Karger AG, Basel
                License:

                This article is licensed under the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC) ( http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.

                History
                Date received : 27 August 2022
                Date accepted : 4 January 2023
                Date: 2023
                Page count
                Figures: 1, References: 7, Pages: 4
                Funding
                No funding was received for this case report.
                Categories
                Subject: Single Case

                ScienceOpen disciplines: Dermatology
                Keywords: vedolizumab,α4β7 integrin,palmoplantar pustulosis
                Data availability:
                ScienceOpen disciplines: Dermatology
                Keywords: vedolizumab, α4β7 integrin, palmoplantar pustulosis

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