Early polymerase chain reaction detection of Chagas disease reactivation in heart transplant patients.

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Abstract

Heart transplantation is a valuable therapeutic option for Chagas disease patients with severe cardiomyopathy. During patient follow-up, the differential diagnosis between cardiac transplant rejection and Chagas disease infection reactivation remains a challenging task, which hinders rapid implementation of the appropriate treatment. Herein we investigate whether polymerase chain reaction (PCR) strategies could facilitate early detection of Trypanosoma cruzi (T cruzi) in transplanted endomyocardial biopsies (EMBs).

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Journal

Journal ID (iso-abbrev): J. Heart Lung Transplant.

Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publisher: Elsevier BV

ISSN (Electronic): 1557-3117

ISSN (Print): 1053-2498

Publication date (Electronic): Jul 2017

Volume: 36

Issue: 7

Affiliations

[1 ] Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: andrea@ufmg.br.

[2 ] Departamento de Genética, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

[3 ] Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

[4 ] Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

[5 ] Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

[6 ] Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

[7 ] Centro de Pesquisas René Rachou, Fiocruz-Minas, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.

[8 ] Departamento de Patologia da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

[9 ] Departamento de Clinica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Article

Publisher Item ID: S1053-2498(17)31648-0

DOI: 10.1016/j.healun.2017.02.018

PubMed ID: 28320630

SO-VID: b81a2a27-59c2-488a-a61d-06030584ae62

History

Keywords: molecular diagnostics,heart transplantation,endomyocardial biopsy,Chagas disease reactivation,polymerase chain reaction

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Keywords: molecular diagnostics, heart transplantation, endomyocardial biopsy, Chagas disease reactivation, polymerase chain reaction

Early polymerase chain reaction detection of Chagas disease reactivation in heart transplant patients.

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European Journal of Microbiology and Immunology

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