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      Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia.

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          Abstract

          Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated.

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          Author and article information

          Journal
          Int J Gynaecol Obstet
          International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
          1879-3479
          0020-7292
          Mar 2016
          : 132
          : 3
          Affiliations
          [1 ] Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
          [2 ] Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Departments of Internal Medicine/Nephrology and Biomedical and Health Informatics, University of Missouri-Kansas City, Kansas City, MO, USA.
          [3 ] Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
          [4 ] Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
          [5 ] Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
          [6 ] Faculty of Medicine, University of Science and Technology, Irbid, Jordan.
          [7 ] Department of Clinical Epidemiology, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
          [8 ] Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
          [9 ] Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: holger.schunemann@mcmaster.ca.
          Article
          S0020-7292(15)00689-X
          10.1016/j.ijgo.2015.07.026
          26643302
          09092cbb-8a54-4b5a-b120-dd61417204c5
          Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
          History

          Cervical intraepithelial neoplasia,Cold knife conization,Cryotherapy,Loop electrical excision procedure,Meta-analysis,Review,Uterine cervical neoplasms

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