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      Bioprinting a skin patch with dual-crosslinked gelatin (GelMA) and silk fibroin (SilMA): An approach to accelerating cutaneous wound healing

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          Abstract

          Clinical settings often face significant obstacles in treating large acute wounds. The alternative of therapeutic approach is needed urgently. Hydrogels derived from natural or synthetic materials may be designed to perform a variety of functions for promoting wound healing. Herein, a 3D bioprinted hydrogel patch is designed for accelerating acute wound healing, which is fabricated with methacryloyl-substituted gelatin (GelMA) and silk fibroin (SilMA) dual-cross-linked by ultraviolet (UV) light. The GelMA with added silk fibroin (GelSilMA) shows improved biodegradation and mechanical properties. Furthermore, SilMA hydrogel can maintain a moisturized healing environment in wound area persistently with adequate degradation capacity. In vivo, GelSilMA (G-S) hydrogel can help to speed wound closure by the improved microenvironment for epidermal tissue regeneration and endogenous collagen generation accordingly. In summary, the G-S hydrogel patch can accelerate acute wound healing efficiently in a relatively simple and inexpensive manner.

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          Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.

          Kan Yue, Grissel Trujillo-de Santiago, Mario Moisés Alvarez … (2015)
          Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of tissue engineering applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental cell research, cell signaling, drug and gene delivery, and bio-sensing.
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            Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

            Tianlong Zhang, Jin Qu, Xin Zhao … (2018)
            Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical significance in healthcare, especially for joints skin wound healing. Here, we designed a kind of self-healing injectable micelle/hydrogel composites with multi-functions as wound dressing for joint skin damage. By combining the dynamic Schiff base and copolymer micelle cross-linking in one system, a series of hydrogels were prepared by mixing quaternized chitosan (QCS) and benzaldehyde-terminated Pluronic®F127 (PF127-CHO) under physiological conditions. The inherent antibacterial property, pH-dependent biodegradation and release behavior were investigated to confirm multi-functions of wound dressing. The hydrogel dressings showed suitable stretchable and compressive property, comparable modulus with human skin, good adhesiveness and fast self-healing ability to bear deformation. The hydrogels exhibited efficient hemostatic performance and biocompatibility. Moreover, the curcumin loaded hydrogel showed good antioxidant ability and pH responsive release profiles. In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model. Taken together, the antibacterial adhesive hydrogels with self-healing and good mechanical property offer significant promise as dressing materials for joints skin wound healing.
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              3D bioprinting for engineering complex tissues.

              Christian Mandrycky, Zongjie Wang, Keekyoung Kim … (2016)
              Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden biomaterials for the construction of complex 3D functional living tissues or artificial organs. While still in its early stages, bioprinting strategies have demonstrated their potential use in regenerative medicine to generate a variety of transplantable tissues, including skin, cartilage, and bone. However, current bioprinting approaches still have technical challenges in terms of high-resolution cell deposition, controlled cell distributions, vascularization, and innervation within complex 3D tissues. While no one-size-fits-all approach to bioprinting has emerged, it remains an on-demand, versatile fabrication technique that may address the growing organ shortage as well as provide a high-throughput method for cell patterning at the micrometer scale for broad biomedical engineering applications. In this review, we introduce the basic principles, materials, integration strategies and applications of bioprinting. We also discuss the recent developments, current challenges and future prospects of 3D bioprinting for engineering complex tissues. Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.
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                Author and article information

                Contributors
                Jihui Ju
                Ruixing Hou
                Journal
                Journal ID (nlm-ta): Mater Today Bio
                Journal ID (iso-abbrev): Mater Today Bio
                Title: Materials Today Bio
                Publisher: Elsevier
                ISSN (Electronic): 2590-0064
                Publication date PMC-release: 14 January 2023
                Publication date Collection: February 2023
                Publication date (Electronic): 14 January 2023
                Volume: 18
                Electronic Location Identifier: 100550
                Affiliations
                [a ]Suzhou Medical College of Soochow University, Suzhou, 215123, China
                [b ]Department of Hand Surgery, Suzhou Ruihua Orthopaedic Hospital, Suzhou, 215104, China
                [c ]Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, 27257, USA
                [d ]Hospital of Medical College of Yangzhou University, Yangzhou, China
                [e ]Department of Human Anatomy, Histology and Embryology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, China
                Author notes
                [∗ ]Corresponding author. hrx2020@ 123456suda.edu.cn
                [∗∗ ]Corresponding author. jjh2020@ 123456suda.edu.cn
                [1]

                These authors contributed equally.

                Article
                Publisher Item ID: S2590-0064(23)00010-8 Publisher ID: 100550
                DOI: 10.1016/j.mtbio.2023.100550
                PMC ID: 9874077
                SO-VID: 60423cd5-497b-432f-8baf-aa2434b84f11
                Copyright © © 2023 The Author(s)
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 14 October 2022
                Date revision received : 15 December 2022
                Date accepted : 11 January 2023
                Categories
                Subject: Full Length Article

                Keywords: dual-cross-linked hydrogel,gelatin,silk fibroin,3d bioprinting,wound healing
                Data availability:
                Keywords: dual-cross-linked hydrogel, gelatin, silk fibroin, 3d bioprinting, wound healing

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