Shared genetic loci between Alzheimer&apos;s disease and multiple sclerosis: Crossroads between neurodegeneration and immune system.

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Abstract

Neuroinflammation is involved in the pathophysiology of Alzheimer's disease (AD), including immune-linked genetic variants and molecular pathways, microglia and astrocytes. Multiple Sclerosis (MS) is a chronic, immune-mediated disease with genetic and environmental risk factors and neuropathological features. There are clinical and pathobiological similarities between AD and MS. Here, we investigated shared genetic susceptibility between AD and MS to identify putative pathological mechanisms shared between neurodegeneration and the immune system.

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Journal

Journal ID (iso-abbrev): Neurobiol Dis

Title: Neurobiology of disease

Publisher: Elsevier BV

ISSN (Electronic): 1095-953X

ISSN (Print): 0969-9961

Publication date (Electronic): Jul 2023

Volume: 183

Affiliations

[1 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: vera.fominykh@medisin.uio.no.

[2 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

[3 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.

[4 ] Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

[5 ] Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

[6 ] Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tonsberg, Vestfold, Norway.

[7 ] Department of Radiology, University of California San Diego, La Jolla, California, USA; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, California, USA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.

[8 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Centre for Neurodevelopmental disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.

[9 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Informatics, Centre for Bioinformatics, University of Oslo, Norway.

[10 ] NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Centre for Neurodevelopmental disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.

Article

Publisher Item ID: S0969-9961(23)00189-4

DOI: 10.1016/j.nbd.2023.106174

PubMed ID: 37286172

SO-VID: 23144f51-7c50-4d0c-b062-933640449975

History

Keywords: Multiple sclerosis,Genetic overlap,Dementia,Alzheimer's disease,Pleiotropy,Neuroinflammation,Neurodegeneration

Data availability:

Keywords: Multiple sclerosis, Genetic overlap, Dementia, Alzheimer's disease, Pleiotropy, Neuroinflammation, Neurodegeneration

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system.

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Alternative approaches to Alzheimer's Disease

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