Work-related musculoskeletal disorders (WMSDs) are responsible for morbidity in many working populations. Apart from lowering the quality of workers' life and reducing the productivity, WMSDs are the most expensive form of work disability, attributing to about 40% of all costs toward the treatment of work-related injuries. WMSDs are considered to be multifactorials that are caused due to the interactions between various risk factors, which result in conditions that vary across different occupations. Although health care profession is known to be at a high risk for WMSDs, it is one of the least-studied occupations. Most of the previous studies on WMSDs among health care workers were limited to any one of the professional groups such as nurses, physical therapists, dentists, and others. Hence this study was aimed at looking into the WMSDs affecting five different health care professionals working in a tertiary care hospital. It compared the prevalence and distribution of WMSDs among the five groups, evaluated the multiple risk factors that contribute to the development of WMSDs, and identified the high-risk group.