PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing.

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Abstract

Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic reprogramming may be involved in VSMC phenotypic transition. However, the definite molecules that link energy metabolism to distinct VSMC phenotype remain elusive.

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Journal

Journal ID (iso-abbrev): Circ Res

Title: Circulation research

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Oct 28 2022

Volume: 131

Issue: 10

Affiliations

[1 ] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, P. R. China (Y.J., C.M., Z.M., J.H., W.L., X.M., S.Z., M.L., F.Y., J.F., Y.Z., Y.F., W.K.).

[2 ] Beijing Institute of Biotechnology, Beijing, P. R. China (C.M.).

[3 ] State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China (Y.S., J.C.).

[4 ] Cardiovascular Division, Kings College London BHF Centre, London SE5 9NU, UK (Q.X.).

[5 ] Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China (Q.X.).

[6 ] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, P. R. China (L.Z.).

Article

DOI: 10.1161/CIRCRESAHA.122.321005

PubMed ID: 36200440

SO-VID: 7d16fefe-a4c7-47c1-8922-93873ff7b804

History

Keywords: neointima,hnRNPA1,restenosis,PKM,vascular smooth muscle cell,glycolysis,prohibitin 2

Data availability:

Keywords: neointima, hnRNPA1, restenosis, PKM, vascular smooth muscle cell, glycolysis, prohibitin 2

PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing.

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