Altered calcium dynamics do not account for attenuation of endothelium-derived hyperpolarizing factor-mediated dilations in the female middle cerebral artery.

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Abstract

The contribution of endothelium-derived hyperpolarizing factor (EDHF) to ATP-mediated dilations is significantly attenuated in the rat middle cerebral artery of intact and estrogen-treated ovariectomized (OVX) females compared with males and vehicle-treated OVX females. Since an increase in endothelial calcium appears to be a critical prerequisite in the EDHF response, we tested the hypothesis that endothelial cell intracellular calcium ([Ca(2+)](i)) fails to reach sufficient levels to elicit robust EDHF-mediated dilations in females and that this effect is mediated by estrogen.

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Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): Dec 2002

Volume: 33

Issue: 12

Affiliations

[1 ] Department of Anesthesiology, Baylor College of Medicine, Houston, Texas, USA. egolding@bcm.tmc.edu

Article

PubMed ID: 12468799

SO-VID: a18d598b-21b6-40f1-b2bc-9fc0a02a5b0f

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