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Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia.
Nancy C Andreasen
1 ,
Peg Nopoulos ,
Vincent Magnotta ,
Ronald Pierson ,
Steven Ziebell ,
Beng-Choon Ho
Oct 01 2011
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Abstract
Schizophrenia has a characteristic onset during adolescence or young adulthood but also tends to persist throughout life. Structural magnetic resonance studies indicate that brain abnormalities are present at onset, but longitudinal studies to assess neuroprogression have been limited by small samples and short or infrequent follow-up intervals.