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Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor
H. Tanoue ,
J. Morinaga ,
T. Yoshizawa ,
M. Yugami ,
H. Itoh ,
T. Nakamura ,
Y. Uehara ,
T. Masuda ,
H. Odagiri ,
T. Sugizaki ,
T. Kadomatsu ,
K. Miyata ,
M. Endo ,
K. Terada ,
H. Ochi ,
S. Takeda ,
K. Yamagata ,
T. Fukuda ,
H. Mizuta ,
Y. Oike
January 2018
January 2018
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Abstract
Chondrocyte differentiation is crucial for long bone growth. Many cartilage extracellular
matrix (ECM) proteins reportedly contribute to chondrocyte differentiation, indicating
that mechanisms underlying chondrocyte differentiation are likely more complex than
previously appreciated. Angiopoietin-like protein 2 (ANGPTL2) is a secreted factor
normally abundantly produced in mesenchymal lineage cells such as adipocytes and fibroblasts,
but its loss contributes to the pathogenesis of lifestyle- or aging-related diseases.
However, the function of ANGPTL2 in chondrocytes, which are also differentiated from
mesenchymal stem cells, remains unclear. Here, we investigate whether ANGPTL2 is expressed
in or functions in chondrocytes.