Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts.

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Abstract

The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women.

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Most cited references 21

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Diabetes

Peter Kahn, Asish Saha, Paul Epstein (1989)

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Resistin, an adipokine with potent proinflammatory properties.

Maria I Bokarewa, Ivan Nagaev, Leif Dahlberg … (2005)

The adipokine resistin is suggested to be an important link between obesity and insulin resistance. In the present study, we assessed the impact of resistin as inflammatogenic cytokine in the setting of arthritis. In vitro experiments on human PBMC were performed to assess cytokine response and transcription pathways of resistin-induced inflammation. Proinflammatory properties of resistin were evaluated in animal model by intra-articular injection of resistin followed by histological evaluation of the joint. Levels of resistin were assessed by ELISA in 74 paired blood and synovial fluid samples of patients with rheumatoid arthritis. Results were compared with the control group comprised blood samples from 34 healthy individuals and 21 synovial fluids from patients with noninflammatory joint diseases. We now show that resistin displays potent proinflammatory properties by 1) strongly up-regulating IL-6 and TNF-alpha, 2) responding to TNF-alpha challenge, 3) enhancing its own activity by a positive feedback, and finally 4) inducing arthritis when injected into healthy mouse joints. Proinflammatory properties of resistin were abrogated by NF-kappaB inhibitor indicating the importance of NF-kappaB signaling pathway for resistin-induced inflammation. Resistin is also shown to specifically accumulate in the inflamed joints of patients with rheumatoid arthritis and its levels correlate with other markers of inflammation. Our results indicate that resistin is a new and important member of the cytokine family with potent regulatory functions. Importantly, the identified properties of resistin make it a novel and interesting therapeutic target in chronic inflammatory diseases such as rheumatoid arthritis.

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A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study.

Y. Song, J E Manson, J E Buring … (2004)

The aim of this study was to prospectively assess the relation between red meat intake and incidence of type 2 diabetes. Over an average of 8.8 years, we evaluated 37,309 participants in the Women's Health Study aged >/=45 years who were free of cardiovascular disease, cancer, and type 2 diabetes and completed validated semiquantitative food frequency questionnaires in 1993. During 326,876 person-years of follow-up, we documented 1,558 incident cases of type 2 diabetes. After adjusting for age, BMI, total energy intake, exercise, alcohol intake, cigarette smoking, and family history of diabetes, we found positive associations between intakes of red meat and processed meat and risk of type 2 diabetes. Comparing women in the highest quintile with those in the lowest quintile, the multivariate-adjusted relative risks (RRs) of type 2 diabetes were 1.28 for red meat (95% CI 1.07-1.53, P /=5/week vs. /=2/week vs. /=2/week vs. <1/week, P = 0.003 for trend). These results remained significant after further adjustment for intakes of dietary fiber, magnesium, glycemic load, and total fat. Intakes of total cholesterol, animal protein, and heme iron were also significantly associated with a higher risk of type 2 diabetes. Our data indicate that higher consumption of total red meat, especially various processed meats, may increase risk of developing type 2 diabetes in women.

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Author and article information

Journal

Journal ID (iso-abbrev): Diabetes Care

Title: Diabetes care

Publisher: American Diabetes Association

ISSN (Electronic): 1935-5548

ISSN (Print): 0149-5992

Publication date (Electronic): Feb 2009

Volume: 32

Issue: 2

Affiliations

[1 ] Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA.

Article

Publisher Item ID: dc08-1625

DOI: 10.2337/dc08-1625

PMC ID: 2628703

PubMed ID: 18957529

SO-VID: 5db0caeb-72fd-4d4e-bdfb-6dd3a58175d4

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Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts.

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Abstract

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Journal of Circulating Biomarkers

Most cited references 21

Diabetes

Resistin, an adipokine with potent proinflammatory properties.

A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study.

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