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Abstract
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4
(Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila
et al. report the identification of a new player in the agrin-MuSK pathway, Tid1,
which directly interacts with MuSK and is responsible for transducing signals from
MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic
cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of
neuromuscular synaptogenesis.