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      Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

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          Abstract

          Herpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to assess the frequency, symptoms, risk factors, and outcomes of this complication.

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          Author and article information

          Journal
          Lancet Neurol
          The Lancet. Neurology
          Elsevier BV
          1474-4465
          1474-4422
          Sep 2018
          : 17
          : 9
          Affiliations
          [1 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit, Neurology Department, Research Institute of Sant Joan de Déu Children's Hospital, University of Barcelona, Barcelona, Spain.
          [2 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; University of Lausanne, Lausanne, Switzerland.
          [3 ] Immunology Department, Centre of Biomedical Diagnosis, Hospital Clínic, University of Barcelona, Barcelona, Spain; Functional Unit of Clinical Immunology, Research Institute of Sant Joan de Déu Children's Hospital, University of Barcelona, Barcelona, Spain.
          [4 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Section of Child Neuropsychiatry, Department of Medical Surgical and Experimental Medicine, University of Sassari (Sassari), Italy.
          [5 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [6 ] Laboratory of Advanced Imaging in Neuroimmunological Diseases (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [7 ] Laboratory of Advanced Imaging in Neuroimmunological Diseases (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [8 ] Department of Radiology, Research Institute of Sant Joan de Déu Children's Hospital, University of Barcelona, Barcelona, Spain.
          [9 ] Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Spain.
          [10 ] Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain.
          [11 ] Department of Neurology, Hospital Central de Asturias, Oviedo, Spain.
          [12 ] Department of Neurology, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
          [13 ] Hospital Universitario Ramon y Cajal, Madrid, Spain.
          [14 ] Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [15 ] Pediatric Neuroimmunology Unit, Neurology Department, Research Institute of Sant Joan de Déu Children's Hospital, University of Barcelona, Barcelona, Spain.
          [16 ] Microbiology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [17 ] Functional Unit of Clinical Immunology, Research Institute of Sant Joan de Déu Children's Hospital, University of Barcelona, Barcelona, Spain.
          [18 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain.
          [19 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA.
          [20 ] Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address: jdalmau@clinic.cat.
          Article
          NIHMS986359 S1474-4422(18)30244-8
          10.1016/S1474-4422(18)30244-8
          6128696
          30049614
          9d49fa27-c261-406f-bb5a-d745a3926730
          History

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