The association of long-term exposure to criteria air pollutants, fine particulate matter components, and airborne trace metals with late-life brain amyloid burden in the Atherosclerosis Risk in Communities (ARIC) study.

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Abstract

Studies suggest associations between long-term ambient air pollution exposure and outcomes related to Alzheimer's disease (AD). Whether a link exists between pollutants and brain amyloid accumulation, a biomarker of AD, is unclear. We assessed whether long-term air pollutant exposures are associated with late-life brain amyloid deposition in Atherosclerosis Risk in Communities (ARIC) study participants.

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Journal

Journal ID (iso-abbrev): Environ Int

Title: Environment international

Publisher: Elsevier BV

ISSN (Electronic): 1873-6750

ISSN (Print): 0160-4120

Publication date (Electronic): Oct 2023

Volume: 180

Affiliations

[1 ] Department of Epidemiology, The George Washington University Milken Institute School of Public Health, Washington, DC, USA. Electronic address: erinbennett@gwu.edu.

[2 ] Department of Epidemiology, The George Washington University Milken Institute School of Public Health, Washington, DC, USA.

[3 ] Department of Epidemiology & Biostatistics, Texas A&M Health Science Center School of Public Health, College Station, TX, USA.

[4 ] Texas A&M Transportation Institute, College Station, TX, USA.

[5 ] Zachry Department of Civil & Environmental Engineering, Texas A&M University, College Station, TX, USA.

[6 ] Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

[7 ] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

[8 ] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

[9 ] The University of Mississippi Medical Center, Jackson, MS, USA.

[10 ] Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

[11 ] Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

[12 ] Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.

[13 ] Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA; Department of Medicine, School of Medicine, University of Washington, Seattle, WA.

[14 ] National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Article

Mid ID: NIHMS1935716 Publisher Item ID: S0160-4120(23)00473-7

DOI: 10.1016/j.envint.2023.108200

PMC ID: 10620775

PubMed ID: 37774459

SO-VID: 80697867-93b8-4211-ac02-b04701880c58

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