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      Three-dimensional preoperative planning in the weight-bearing state: validation and clinical evaluation

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          Abstract

          Objectives

          3D preoperative planning of lower limb osteotomies has become increasingly important in light of modern surgical technologies. However, 3D models are usually reconstructed from Computed Tomography data acquired in a non-weight-bearing posture and thus neglecting the positional variations introduced by weight-bearing. We developed a registration and planning pipeline that allows for 3D preoperative planning and subsequent 3D assessment of anatomical deformities in weight-bearing conditions.

          Methods

          An intensity-based algorithm was used to register CT scans with long-leg standing radiographs and subsequently transform patient-specific 3D models into a weight-bearing state. 3D measurement methods for the mechanical axis as well as the joint line convergence angle were developed. The pipeline was validated using a leg phantom. Furthermore, we evaluated our methods clinically by applying it to the radiological data from 59 patients.

          Results

          The registration accuracy was evaluated in 3D and showed a maximum translational and rotational error of 1.1 mm (mediolateral direction) and 1.2° (superior-inferior axis). Clinical evaluation proved feasibility on real patient data and resulted in significant differences for 3D measurements when the effects of weight-bearing were considered. Mean differences were 2.1 ± 1.7° and 2.0 ± 1.6° for the mechanical axis and the joint line convergence angle, respectively. 37.3 and 40.7% of the patients had differences of 2° or more in the mechanical axis or joint line convergence angle between weight-bearing and non-weight-bearing states.

          Conclusions

          Our presented approach provides a clinically feasible approach to preoperatively fuse 2D weight-bearing and 3D non-weight-bearing data in order to optimize the surgical correction.

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          Most cited references33

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          Deformity planning for frontal and sagittal plane corrective osteotomies.

          The authors have developed a universal system of geometric deformity planning based on the mechanical or anatomic axes. The place where the axes intersect is the center of rotation angulation (CORA) of a deformity. Osteotomy level and type should be considered relative to the CORA to avoid creating secondary deformities. This type of planning is applicable to both frontal and sagittal plane deformities.
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            • Article: not found

            Cluster analysis of multivariate data: efficiency versus interpretability of classifications

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              • Article: not found

              Varus and valgus alignment and incident and progressive knee osteoarthritis.

              Varus and valgus alignment increase medial and lateral tibiofemoral load. Alignment was associated with tibiofemoral osteoarthritis progression in previous studies; an effect on incident osteoarthritis risk is less certain. This study tested whether alignment influences the risk of incident and progressive radiographic tibiofemoral osteoarthritis. In an observational, longitudinal study of the Multicenter Osteoarthritis Study cohort, full-limb x-rays to measure alignment were acquired at baseline and knee x-rays were acquired at baseline and knee x-rays at baseline and 30 months. Varus alignment was defined as ≤178° and valgus ≥182°. Using logistic regression and generalised estimating equations, the associations of baseline alignment and incident osteoarthritis at 30 months (in knees without baseline osteoarthritis) and alignment and osteoarthritis progression (in knees with osteoarthritis) were examined, adjusting. For age, gender, body mass index, injury, laxity and strength, with neutral knees as referent. 2958 knees (1752 participants) were without osteoarthritis at baseline. Varus (adjusted OR 1.49, 95% CI 1.06 to 2.10) but not valgus alignment was associated with incident osteoarthritis. 1307 knees (950 participants) had osteoarthritis at baseline. Varus alignment was associated with a greater risk of medial osteoarthritis progression (adjusted OR 3.59, 95% CI 2.62 to 4.92) and a reduced risk of lateral progression, and valgus with a greater risk of lateral progression (adjusted OR 4.85, 95% CI 3.17 to 7.42) and a reduced risk of medial progression. Varus but not valgus alignment increased the risk of incident tibiofemoral osteoarthritis. In knees with osteoarthritis, varus and valgus alignment each increased the risk of progression in the biomechanically stressed compartment.
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                Author and article information

                Contributors
                tabitha.roth@balgrist.ch
                Journal
                Insights Imaging
                Insights Imaging
                Insights into Imaging
                Springer International Publishing (Cham )
                1869-4101
                7 April 2021
                7 April 2021
                December 2021
                : 12
                : 44
                Affiliations
                [1 ]GRID grid.5801.c, ISNI 0000 0001 2156 2780, Institute for Biomechanics, , ETH Zurich, ; Leopold-Ruzicka-Weg 4, 8093 Zurich, Switzerland
                [2 ]GRID grid.7400.3, ISNI 0000 0004 1937 0650, Research in Orthopedic Computer Science (ROCS), , University Hospital Balgrist, University of Zurich, ; Balgrist Campus, Lengghalde 5, 8008 Zurich, Switzerland
                [3 ]ImFusion GmbH, Agnes-Pockels-Bogen 1, 80992 Munich, Germany
                [4 ]GRID grid.7400.3, ISNI 0000 0004 1937 0650, Department of Radiology, , Balgrist University Hospital, University of Zurich, ; Forchstrasse 340, 8008 Zurich, Switzerland
                [5 ]GRID grid.7400.3, ISNI 0000 0004 1937 0650, Department of Orthopedics, , Balgrist University Hospital, University of Zurich, ; Forchstrasse 340, 8008 Zurich, Switzerland
                Author information
                http://orcid.org/0000-0002-2342-9710
                Article
                994
                10.1186/s13244-021-00994-8
                8026795
                33825985
                4e342193-8870-471c-a147-316d46bc18e4
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 18 January 2021
                : 24 March 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001711, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung;
                Award ID: 320030_182352 / 1
                Award Recipient :
                Categories
                Original Article
                Custom metadata
                © The Author(s) 2021

                Radiology & Imaging
                3d preoperative planning,weight-bearing,osteotomy,2d–3d registration,3d measurement methods

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