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      Attention-Deficit/Hyperactivity Disorder Diagnoses in Finland During the COVID-19 Pandemic

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      , MD, PhD 1 , 2 , 3 , , , MSc 3 , , MD, PhD 3 , , DSc 3 , 4 , , MD, PhD 1 , 2
      JAMA Network Open
      American Medical Association

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          Abstract

          This cohort study evaluates trends in new attention-deficit/hyperactivity disorder (ADHD) diagnoses, prevalence, and ADHD medication use before and during the COVID-19 pandemic in Finland.

          Key Points

          Question

          Did attention-deficit/hyperactivity disorder (ADHD) increase during the COVID-19 pandemic in the Finnish population?

          Findings

          In this cohort study with more than 5.5 million participants, new ADHD diagnoses doubled during the pandemic between 2020 and 2022 in Finland; a significant increase in ADHD was observed in the population, except among male participants younger than 21 years and among adults older than 55 years. The largest, 3-fold increase was observed in female participants aged 13 to 30 years.

          Meaning

          These findings suggest new ADHD diagnoses increased significantly in Finland during the pandemic.

          Abstract

          Importance

          Several reports suggest an increase in attention-deficit/hyperactivity disorder (ADHD) symptoms during the COVID-19 pandemic. This nationwide study assessed new ADHD diagnoses and ADHD prevalence before and during the pandemic.

          Objective

          To investigate trends in new ADHD diagnoses, prevalence, and ADHD medication use from 2015 to 2022 in Finland.

          Design, Setting, and Participants

          This longitudinal cohort study comprised the entire Finnish population. ADHD diagnoses and medication use were obtained from nationwide registers and assessed at 3 time points: in 2015 and before (2020) and after (2022) the pandemic. Data were analyzed from January 2015 to June 2022.

          Main outcomes and Measures

          New ADHD diagnoses, ADHD lifetime prevalence, and ADHD medication use.

          Results

          The cohort comprised 5 572 420 individuals (2 819 645 women [50.6%]). Lifetime prevalence of ADHD increased by 2.7-fold during 2015 to 2022; prevalence was 1.02% in 2015 (95% CI, 1.01%-1.03%), 1.80% in 2020 (95% CI, 1.79%-1.81%), and 2.76% in 2022 (95% CI, 2.75%-2.77%). Young men aged 13 to 20 years had the highest lifetime prevalence of 11.68% (95% CI, 11.56%-11.81%) in 2022. New ADHD diagnoses doubled during the pandemic, from 238 per 100 000 in 2020 to 477 per 100 000 in 2022. The pandemic-associated incremental increase in new diagnoses was 18.60% (95% CI, 16.47%-20.49%; 9482 per 50 897 cases). Young women aged 13 to 20 years had a 2.6-fold increase in new diagnoses during the pandemic, from 577 per 100 000 in 2020 to 1488 per 100 000 in 2022, and women aged 21 to 30 years had a 3.0-fold increase, from 361 per 100 000 to 1100 per 100 000. New diagnoses increased by 2.9-fold among those older than 55 years (from 5 per 100 000 to 13 per 100 000 in women and from 5 per 100 000 to 14 per 100 000 in men). Boys younger than 13 years had the highest absolute rate of new ADHD diagnoses in 2022 (1745 per 100 000), but boys and young men younger than 21 years did not show a significant incremental increase in new diagnoses. Lifetime prevalence of ADHD medication purchases was 0.57% (95% CI, 0.56%-0.58%) in 2015 (31 771 [55.62%] of those with ADHD diagnosis), 1.15% (95% CI, 1.14%-1.16%) in 2020 (64 034 [63.83%]), and 1.69% (95% CI 1.68%-1.70%) in 2022 (92 557 [61.43%]), respectively.

          Conclusions and Relevance

          In this nationwide cohort study, new ADHD diagnoses and ADHD prevalence showed significant increase in Finland during the pandemic. ADHD medication use did not increase in relation to ADHD diagnoses. These results highlight potential adverse outcomes of pandemic-associated changes in living conditions.

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          Most cited references55

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          The Mental Health Consequences of COVID-19 and Physical Distancing: The Need for Prevention and Early Intervention

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            Is Open Access

            Effects of COVID-19 on College Students’ Mental Health in the United States: Interview Survey Study

            Background Student mental health in higher education has been an increasing concern. The COVID-19 pandemic situation has brought this vulnerable population into renewed focus. Objective Our study aims to conduct a timely assessment of the effects of the COVID-19 pandemic on the mental health of college students. Methods We conducted interview surveys with 195 students at a large public university in the United States to understand the effects of the pandemic on their mental health and well-being. The data were analyzed through quantitative and qualitative methods. Results Of the 195 students, 138 (71%) indicated increased stress and anxiety due to the COVID-19 outbreak. Multiple stressors were identified that contributed to the increased levels of stress, anxiety, and depressive thoughts among students. These included fear and worry about their own health and of their loved ones (177/195, 91% reported negative impacts of the pandemic), difficulty in concentrating (173/195, 89%), disruptions to sleeping patterns (168/195, 86%), decreased social interactions due to physical distancing (167/195, 86%), and increased concerns on academic performance (159/195, 82%). To cope with stress and anxiety, participants have sought support from others and helped themselves by adopting either negative or positive coping mechanisms. Conclusions Due to the long-lasting pandemic situation and onerous measures such as lockdown and stay-at-home orders, the COVID-19 pandemic brings negative impacts on higher education. The findings of our study highlight the urgent need to develop interventions and preventive strategies to address the mental health of college students.
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              Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: a longitudinal observational study

              Background There is major concern about the impact of the global COVID-19 outbreak on mental health. Several studies suggest that mental health deteriorated in many countries before and during enforced isolation (ie, lockdown), but it remains unknown how mental health has changed week by week over the course of the COVID-19 pandemic. This study aimed to explore the trajectories of anxiety and depression over the 20 weeks after lockdown was announced in England, and compare the growth trajectories by individual characteristics. Methods In this prospective longitudinal observational study, we analysed data from the UCL COVID-19 Social Study, a panel study weighted to population proportions, which collects information on anxiety (using the Generalised Anxiety Disorder assessment) and depressive symptoms (using the Patient Health Questionnaire) weekly in the UK since March 21, 2020. We included data from adults living in England who had at least three repeated measures between March 23 and Aug 9, 2020. Analyses were done using latent growth models, which were fitted to account for sociodemographic and health covariates. Findings Between March 23, and Aug 9, data from over 70 000 adults were collected in the UCL COVID-19 Social Study. When including participants living in England with three follow-up measures and no missing values, our analytic sample consisted of 36 520 participants. The average depression score was 6·6 (SD=6·0, range 0–27) and the average anxiety score 5·7 (SD=5·6, range 0–21) in week 1. Anxiety and depression levels both declined across the first 20 weeks following the introduction of lockdown in England (b=–1·93, SE=0·26, p<0·0001 for anxiety; b=–2·52, SE=0·28, p<0·0001 for depressive symptoms). The fastest decreases were seen across the strict lockdown period (between weeks 2 and 5), with symptoms plateauing as further lockdown easing measures were introduced (between weeks 16 and 20). Being a woman or younger, having lower educational attainment, lower income, or pre-existing mental health conditions, and living alone or with children were all risk factors for higher levels of anxiety and depression at the start of lockdown. Many of these inequalities in experiences were reduced as lockdown continued, but differences were still evident 20 weeks after the start of lockdown. Interpretation These data suggest that the highest levels of depression and anxiety occurred in the early stages of lockdown but declined fairly rapidly, possibly because individuals adapted to circumstances. Our findings emphasise the importance of supporting individuals in the lead-up to future lockdowns to try to reduce distress, and highlight that groups already at risk for poor mental health before the pandemic have remained at risk throughout lockdown and its aftermath. Funding Nuffield Foundation, UK Research and Innovation, Wellcome Trust.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                27 June 2024
                June 2024
                27 June 2024
                : 7
                : 6
                : e2418204
                Affiliations
                [1 ]Division of Adolescent Psychiatry, Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland
                [2 ]Faculty of Medicine, University of Helsinki, Clinicum, Helsinki, Finland
                [3 ]Department of Public Health and Welfare, Finnish Institute for Health and Welfare-THL, Helsinki, Finland
                [4 ]Institute for Molecular Medicine Finland, FIMM-HiLIFE, University of Helsinki, Helsinki, Finland
                Author notes
                Article Information
                Accepted for Publication: April 3, 2024.
                Published: June 27, 2024. doi:10.1001/jamanetworkopen.2024.18204
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2024 Auro K et al. JAMA Network Open.
                Corresponding Author: Kirsi Auro, MD, PhD, Division of Adolescent Psychiatry, Department of Psychiatry, Helsinki University Hospital, Välskärinkatu 12, 00250 Helsinki, Finland ( kirsi.auro@ 123456hus.fi ).
                Author Contributions: Dr Auro had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: Auro, Havulinna, Raevuori.
                Acquisition, analysis, or interpretation of data: All authors.
                Drafting of the manuscript: Auro, Holopainen, Raevuori.
                Critical review of the manuscript for important intellectual content: Auro, Perola, Havulinna.
                Statistical analysis: Holopainen, Havulinna.
                Obtained funding: Auro, Perola, Raevuori.
                Administrative, technical, or material support: Perola, Havulinna.
                Supervision: Auro, Raevuori.
                Conflict of Interest Disclosures: Dr Havulinna reported receiving grants from the Research Council of Finland outside the submitted work. Dr Raevuori reported receiving a lecture fee for an eating disorder lecture from Lundbeck Pharmaceutical and holding equity ownership in Meru Health Inc outside the submitted work. Dr Auro reported receiving consultation fees from GSK outside the submitted work. No other disclosures were reported.
                Funding/Support: This study was funded by Päivikki and Sakari Sohlberg Foundation (to Drs Auro and Holopainen), Helsinki University Hospital research grant, No. Y2112 (to Dr Raevuori), and The Research Counsil of Finland, No. 335525 (to Dr Havulinna) and No. 359072 (to Dr Perola).
                Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Data Sharing Statement: See Supplement 3.
                Article
                zoi240598
                10.1001/jamanetworkopen.2024.18204
                11211961
                38935377
                ab716cc6-428f-42b1-b54d-0604c6d2b8eb
                Copyright 2024 Auro K et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 24 November 2023
                : 3 April 2024
                Categories
                Research
                Original Investigation
                Online Only
                Psychiatry

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