The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology.

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Abstract

The relevance of the microbe-gut-brain axis to psychopathology is of interest in anorexia nervosa (AN), as the intestinal microbiota plays a critical role in metabolic function and weight regulation.

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Most cited references 39

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Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex.

Micah Hamady, Jeffrey Walker, J Kirk Harris … (2008)

We constructed error-correcting DNA barcodes that allow one run of a massively parallel pyrosequencer to process up to 1,544 samples simultaneously. Using these barcodes we processed bacterial 16S rRNA gene sequences representing microbial communities in 286 environmental samples, corrected 92% of sample assignment errors, and thus characterized nearly as many 16S rRNA genes as have been sequenced to date by Sanger sequencing.

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Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.

L Desbonnet, L Garrett, G Clarke … (2010)

The concept that intestinal microbial composition not only affects the health of the gut, but also influences centrally-mediated systems involved in mood, is supported by a growing body of literature. Despite the emergent interest in brain-gut communication and its possible role in the pathogenesis of psychiatric disorders such as depression, particularly subtypes with accompanying gastrointestinal (GI) symptoms, there are few studies dedicated to the search for therapeutic solutions that address both central and peripheral facets of these illnesses. This study aims to assess the potential benefits of the probiotic Bifidobacterium infantis in the rat maternal separation (MS) model, a paradigm that has proven to be of value in the study of stress-related GI and mood disorders. MS adult rat offsprings were chronically treated with bifidobacteria or citalopram and subjected to the forced swim test (FST) to assess motivational state. Cytokine concentrations in stimulated whole blood samples, monoamine levels in the brain, and central and peripheral hypothalamic-pituitary-adrenal (HPA) axis measures were also analysed. MS reduced swim behavior and increased immobility in the FST, decreased noradrenaline (NA) content in the brain, and enhanced peripheral interleukin (IL)-6 release and amygdala corticotrophin-releasing factor mRNA levels. Probiotic treatment resulted in normalization of the immune response, reversal of behavioral deficits, and restoration of basal NA concentrations in the brainstem. These findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered. Copyright © 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

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The core gut microbiome, energy balance and obesity.

Peter J. Turnbaugh, Jeffrey Gordon (2009)

Metagenomics is an emerging field focused on characterizing the structures, functions and dynamic operations of microbial communities sampled in their native habitats without the need for culture. Here, we present findings from a 16S rRNA gene sequence- and whole community DNA shotgun sequencing-based analysis of the adult human gut microbiomes of lean and obese mono- and dizygotic twins. Our findings indicate that a core microbiome can be found at the gene level, despite large variation in community membership, and that variations from the core are associated with obesity. These findings have implications for ongoing Human Microbiome Project(s), and highlight important challenges to the field of metagenomics.

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Journal

Journal ID (iso-abbrev): Psychosom Med

Title: Psychosomatic medicine

ISSN (Electronic): 1534-7796

ISSN (Print): 0033-3174

Publication date (Electronic):

Volume: 77

Issue: 9

Affiliations

[1 ] From the Departments of Nutrition (Kleiman, Bulik), Psychiatry (Watson, Tarantino, Bulik), and Medicine (Huh, Carroll), the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Eating Disorders Program, Child and Adolescent Health Service, Department of Health in Western Australia (Watson), Australia; School of Psychology and Speech Pathology (Watson), Curtin University, Australia; School of Paediatrics and Child Health (Watson), The University of Western Australia, Australia; Kenyon College, United States (Bulik-Sullivan); and Department of Medical Epidemiology and Biostatistics (Bulik), Karolinska Institutet, Stockholm, Sweden.

Article

Mid ID: NIHMS717099

DOI: 10.1097/PSY.0000000000000247

PMC ID: 4643361

PubMed ID: 26428446

SO-VID: 71f42b3e-3e33-4d20-b7e5-61e5725c850d

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The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology.

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Abstract

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Microbiota and Host

Most cited references 39

Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex.

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.

The core gut microbiome, energy balance and obesity.

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Article

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