Efficacy and Safety of Two-Drug Regimens with Dolutegravir plus Rilpivirine or Lamivudine in HIV-1 Virologically Suppressed People Living with HIV.

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Abstract

The high effectiveness and safety of the two-drug (2DRs) strategy using dolutegravir (DTG) plus lamivudine (3TC) have led to international guidelines recommending their use for treatment-naive HIV patients. In virologically suppressed patients, de-escalating from 3DRs to DTG plus either rilpivirine (RPV) or 3TC has shown high rates of virological suppression.

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Author and article information

Journal

Journal ID (iso-abbrev): Viruses

Title: Viruses

Publisher: MDPI AG

ISSN (Electronic): 1999-4915

ISSN (Print): 1999-4915

Publication date (Electronic): Apr 10 2023

Volume: 15

Issue: 4

Affiliations

[1 ] Infectious Diseases Division, Hospital Universitario Clínico de Valladolid, 47003 Valladolid, Spain.

[2 ] Infectious Diseases Division, Hospital Universitario de Burgos, 09006 Burgos, Spain.

[3 ] Infanta Leonor University Hospital Research and Innovation Foundation, 28031 Madrid, Spain.

[4 ] Infectious Diseases Department, Hospital Universitario de Donostia, 20014 San Sebastián, Spain.

[5 ] Infectious Diseases Division, Hospital Universitario de La Princesa, 28006 Madrid, Spain.

[6 ] Infectious Diseases Division, Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain.

[7 ] Infectious Diseases Division, Hospital Universitario de Txagorritxu, 01009 Vitoria, Spain.

[8 ] Infectious Diseases Division, HospitalÁlvaro Cunqueiro, 36312 Vigo, Spain.

[9 ] Infectious Diseases Division, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.

[10 ] Infectious Diseases Division, Hospital de Segovia, 47002 Segovia, Spain.

[11 ] Infectious Diseases Division, Hospital Universitario de Salamanca, 37007 Salamanca, Spain.

[12 ] Internal Medicine Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.

Article

Publisher Item ID: v15040936

DOI: 10.3390/v15040936

PMC ID: 10145987

PubMed ID: 37112915

SO-VID: 3d215fbd-a153-4b2a-9c1f-6e9165419c71

History

Keywords: 2DR,virologically suppressed patients,HIV/AIDS

Data availability:

Keywords: 2DR, virologically suppressed patients, HIV/AIDS

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