Right dorsolateral prefrontal cortex regulates default prosociality preference.

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Abstract

The dorsolateral prefrontal cortex has been shown to be associated with prosocial behavior. However, the direction of this relationship remains controversial. To resolve inconsistencies in the existing literature, we introduced the concept of default prosociality preference and hypothesized that this preference moderates the relationship between gray matter volume in the dorsolateral prefrontal cortex and prosocial behavior. This study analyzed the data of 168 participants obtained from voxel-based morphometry, 4 types of economic games, and 3 different measures of social value orientation that represent default prosociality preference. Here we show that, in individuals who were consistently classified as proself on the 3 social value orientation measures, gray matter volume in the right dorsolateral prefrontal cortex was positively associated with prosocial behavior. However, in individuals who were consistently classified as prosocial, the direction of this association was vice versa. These results indicate that the right dorsolateral prefrontal cortex regulates default prosociality preference.

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An integrative theory of prefrontal cortex function.

E K Miller, J D Cohen (2001)

The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed

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Self-control in decision-making involves modulation of the vmPFC valuation system.

Todd A. Hare, Colin F Camerer, Antonio Rangel (2009)

Every day, individuals make dozens of choices between an alternative with higher overall value and a more tempting but ultimately inferior option. Optimal decision-making requires self-control. We propose two hypotheses about the neurobiology of self-control: (i) Goal-directed decisions have their basis in a common value signal encoded in ventromedial prefrontal cortex (vmPFC), and (ii) exercising self-control involves the modulation of this value signal by dorsolateral prefrontal cortex (DLPFC). We used functional magnetic resonance imaging to monitor brain activity while dieters engaged in real decisions about food consumption. Activity in vmPFC was correlated with goal values regardless of the amount of self-control. It incorporated both taste and health in self-controllers but only taste in non-self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC.

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The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value.

Oscar Bartra, Joseph T McGuire, Joseph W Kable (2013)

Numerous experiments have recently sought to identify neural signals associated with the subjective value (SV) of choice alternatives. Theoretically, SV assessment is an intermediate computational step during decision making, in which alternatives are placed on a common scale to facilitate value-maximizing choice. Here we present a quantitative, coordinate-based meta-analysis of 206 published fMRI studies investigating neural correlates of SV. Our results identify two general patterns of SV-correlated brain responses. In one set of regions, both positive and negative effects of SV on BOLD are reported at above-chance rates across the literature. Areas exhibiting this pattern include anterior insula, dorsomedial prefrontal cortex, dorsal and posterior striatum, and thalamus. The mixture of positive and negative effects potentially reflects an underlying U-shaped function, indicative of signal related to arousal or salience. In a second set of areas, including ventromedial prefrontal cortex and anterior ventral striatum, positive effects predominate. Positive effects in the latter regions are seen both when a decision is confronted and when an outcome is delivered, as well as for both monetary and primary rewards. These regions appear to constitute a "valuation system," carrying a domain-general SV signal and potentially contributing to value-based decision making. Copyright © 2013 Elsevier Inc. All rights reserved.

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Author and article information

Journal

Journal ID (iso-abbrev): Cereb Cortex

Title: Cerebral cortex (New York, N.Y. : 1991)

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2199

ISSN (Print): 1047-3211

Publication date (Electronic): Nov 17 2022

Affiliations

[1 ] Brain Science Institute, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo, 194-8610, Japan.

[2 ] Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo, 194-8610, Japan.

[3 ] School of Social Informatics, Aoyama Gakuin University, 5-10-1 Fuchinobe, Sagamihara, Kanagawa, 252-5258, Japan.

Article

Publisher Item ID: 6832153

DOI: 10.1093/cercor/bhac429

PubMed ID: 36396873

SO-VID: e031c25c-8e94-44a2-abf8-8ee30110e817

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Keywords: dorsolateral prefrontal cortex,voxel-based morphometry,economic game,brain structure,social value orientation

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Keywords: dorsolateral prefrontal cortex, voxel-based morphometry, economic game, brain structure, social value orientation

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Right dorsolateral prefrontal cortex regulates default prosociality preference.

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Most cited references 37

An integrative theory of prefrontal cortex function.

Self-control in decision-making involves modulation of the vmPFC valuation system.

The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value.

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