Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease.

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Abstract

Growth differentiation factor 15 (GDF-15) is expressed and secreted in response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. Cardiovascular (CV) disease is a major driver of GDF-15 production. GDF-15 has favorable preanalytic characteristics and can be measured in serum and plasma by immunoassay.

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Journal

Journal ID (iso-abbrev): Clin. Chem.

Title: Clinical chemistry

Publisher: American Association for Clinical Chemistry (AACC)

ISSN (Electronic): 1530-8561

ISSN (Print): 0009-9147

Publication date (Electronic): Jan 2017

Volume: 63

Issue: 1

Affiliations

[1 ] Division of Molecular and Translational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; wollert.kai@mh-hannover.de.

[2 ] Division of Molecular and Translational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

[3 ] Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

Article

Publisher Item ID: clinchem.2016.255174

DOI: 10.1373/clinchem.2016.255174

PubMed ID: 28062617

SO-VID: 131f9e41-f983-4fd1-8ee1-0625f62cf91f

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