The conserved long non-coding RNA CARMA regulates cardiomyocyte differentiation.

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Abstract

Production of functional cardiomyocytes from pluripotent stem cells requires tight control of the differentiation process. Long non-coding RNAs (lncRNAs) exert critical regulatory functions in cell specification during development. In this study, we designed an integrated approach to identify lncRNAs implicated in cardiogenesis in differentiating human embryonic stem cells (ESCs).

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Author and article information

Journal

Journal ID (iso-abbrev): Cardiovasc Res

Title: Cardiovascular research

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1755-3245

ISSN (Print): 0008-6363

Publication date (Electronic): Jul 27 2022

Volume: 118

Issue: 10

Affiliations

[1 ] Department of Molecular Genetics, Faculty of Biological Sciences Tarbiat Modares University, Tehran, Iran.

[2 ] Experimental Cardiology Unit, Division of Cardiology, Department of Cardiovascular Medicine, University of Lausanne Medical School, Lausanne, Switzerland.

[3 ] Department of Biomedical Research, University of Bern, Bern, Switzerland.

[4 ] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran.

Article

Publisher Item ID: 6359815

DOI: 10.1093/cvr/cvab281

PubMed ID: 34459880

SO-VID: a09a4624-d46f-4fe1-8c61-04056dfaffa8

History

Keywords: Long non-coding RNAs,Cardiomyocyte differentiation,Embryonic stem cells,NOTCH,miR-1-1,miR-133a2

Data availability:

Keywords: Long non-coding RNAs, Cardiomyocyte differentiation, Embryonic stem cells, NOTCH, miR-1-1, miR-133a2

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