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      Palm Dates Protect Memory Formation in Diabetes Mellitus: Neutralization of Oxidative Stress

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          Abstract

          Background:

          Diabetes Mellitus (DM) is associated with spatial memory impairment that is attributed to the oxidative imbalance in the brain. Palm dates were reported to have neuroprotective and antioxidant effects. This investigation examined palm date consumption for its impact on the decline in cognitive function and oxidative imbalance associated with DM using the streptozotocin (STZ) rat model.

          Methods:

          The palm dates extract was administered to rats orally (3.2 g per kg of body weight) for eight weeks. Memory assessment was performed using the Radial Arm Water Maze (RAWM). Hippocampal biomarkers of oxidative stress were evaluated.

          Results:

          STZ-treated animals revealed significant spatial memory impairment (short-and long-term) ( P<0.05). Date consumption for eight weeks prevented the decline in spatial memory induced by STZ ( P<0.05). STZ administration induced oxidation imbalance in the hippocampus as marked by the significant reduction in the activity of glutathione peroxidase (GPx), reduced glutathione (GSH) levels, and GSH/GSSG ratio as well as raised levels of oxidized glutathione (GSSG) ( P<0.05). Date consumption for eight weeks prevented oxidative imbalance induced by STZ in the hippocampus ( P<0.05).

          Conclusion:

          This study has verified the beneficial effect of palm dates on cognitive impairment and oxidative imbalance associated with DM.

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          Most cited references46

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          WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

          To provide global estimates of diabetes prevalence for 2019 and projections for 2030 and 2045.
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            Antioxidant activity applying an improved ABTS radical cation decolorization assay

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              Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents

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                Author and article information

                Journal
                The Open Agriculture Journal
                TOASJ
                Bentham Science Publishers Ltd.
                1874-3315
                August 07 2023
                August 07 2023
                : 17
                : 1
                Article
                10.2174/18743315-v17-230726-2023-29
                97a3af19-7219-4f7a-8626-cb1d9d8ec14f
                © 2023

                Free to read

                https://creativecommons.org/licenses/by/4.0/legalcode

                History

                Medicine,Chemistry,Life sciences
                Medicine, Chemistry, Life sciences

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