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      Depression and Posttraumatic Stress Symptoms After Perinatal Loss in a Population-Based Sample

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      , MD, MSW, MS 1, , 2 , , , PhD 2 , , BS, CCRC 1 , , PhD 1, , 3
      Journal of Women's Health
      Mary Ann Liebert, Inc.

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          Abstract

          Introduction: Perinatal loss is often a traumatic outcome for families. While there are limited data about depressive outcomes in small populations, information about depression and posttraumatic stress disorder among large racially and economically diverse populations is sparse.

          Methods: We collaborated with the Michigan Department of Community Health to conduct a longitudinal survey of bereaved mothers with stillbirth or infant death under 28 days of life and live-birth (control) mothers in Michigan. The study assessed 9-month mental health outcomes including self-reported symptoms of depression and posttraumatic stress disorder along with information about demographics, pregnancy and loss experience, social support, and past and present mental health and treatment.

          Results: Of 1400 women contacted by the State of Michigan, 609 completed surveys and were eligible to participate for a 44% response rate (377 bereaved mothers and 232 control mothers with live births). In multivariable analysis, bereaved women had nearly 4-fold higher odds of having a positive screen for depression and 7-fold higher odds of a positive screen for post-traumatic stress disorder after controlling for demographic and personal risk variables. A minority of screen-positive women were receiving any type of psychiatric treatment.

          Conclusion: This is the largest epidemiologically based study to date to measure the psychological impact of perinatal loss. Nine months after a loss, bereaved women showed high levels of distress with limited rates of treatment. Symptoms need to be monitored over time for persisting disorder and further research should identify women at highest risk for poor outcomes.

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          Most cited references34

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          Diagnostic and Statistical Manual of Mental Disorders

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            The PHQ-8 as a measure of current depression in the general population.

            The eight-item Patient Health Questionnaire depression scale (PHQ-8) is established as a valid diagnostic and severity measure for depressive disorders in large clinical studies. Our objectives were to assess the PHQ-8 as a depression measure in a large, epidemiological population-based study, and to determine the comparability of depression as defined by the PHQ-8 diagnostic algorithm vs. a PHQ-8 cutpoint > or = 10. Random-digit-dialed telephone survey of 198,678 participants in the 2006 Behavioral Risk Factor Surveillance Survey (BRFSS), a population-based survey in the United States. Current depression as defined by either the DSM-IV based diagnostic algorithm (i.e., major depressive or other depressive disorder) of the PHQ-8 or a PHQ-8 score > or = 10; respondent sociodemographic characteristics; number of days of impairment in the past 30 days in multiple domains of health-related quality of life (HRQoL). The prevalence of current depression was similar whether defined by the diagnostic algorithm or a PHQ-8 score > or = 10 (9.1% vs. 8.6%). Depressed patients had substantially more days of impairment across multiple domains of HRQoL, and the impairment was nearly identical in depressed groups defined by either method. Of the 17,040 respondents with a PHQ-8 score > or = 10, major depressive disorder was present in 49.7%, other depressive disorder in 23.9%, depressed mood or anhedonia in another 22.8%, and no evidence of depressive disorder or depressive symptoms in only 3.5%. The PHQ-8 diagnostic algorithm rather than an independent structured psychiatric interview was used as the criterion standard. The PHQ-8 is a useful depression measure for population-based studies, and either its diagnostic algorithm or a cutpoint > or = 10 can be used for defining current depression.
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              Statistical Analysis with Missing Data

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                Author and article information

                Journal
                J Womens Health (Larchmt)
                J Womens Health (Larchmt)
                jwh
                Journal of Women's Health
                Mary Ann Liebert, Inc. (140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA )
                1540-9996
                1931-843X
                01 March 2016
                : 25
                : 3
                : 263-269
                Affiliations
                [ 1 ]Department of Family Medicine, University of Michigan , Ann Arbor, Michigan.
                [ 2 ]Department of Obstetrics and Gynecology, University of Michigan , Ann Arbor, Michigan.
                [ 3 ]Department of Biostatistics, University of Michigan , Ann Arbor, Michigan.
                Author notes
                Address correspondence to: Katherine J. Gold, MD, MSW, MS, Department of Family Medicine, University of Michigan 1018 Fuller Street, Ann Arbor, MI 48104-1213, E-mail: ktgold@ 123456umich.edu
                Article
                PMC4955602 PMC4955602 4955602 10.1089/jwh.2015.5284
                10.1089/jwh.2015.5284
                4955602
                26258870
                44b04f1d-d531-44c1-ade5-c1684022b14e
                Copyright 2016, Mary Ann Liebert, Inc.
                History
                Page count
                Tables: 2, References: 46, Pages: 7
                Categories
                Original Articles

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