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Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats
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Abstract
In advanced cirrhosis, gut bacterial translocation is the consequence of intestinal
barrier disruption and leads to bacterial infection. Bile acid abnormalities in cirrhosis
could play a role in the integrity of the intestinal barrier and the control of microbiota,
mainly through the farnesoid X receptor. We investigated the long-term effects of
the farnesoid X receptor agonist, obeticholic acid, on gut bacterial translocation,
intestinal microbiota composition, barrier integrity and inflammation in rats with
CCl4-induced cirrhosis with ascites.