Liraglutide With Metformin Therapy Ameliorates Hepatic Steatosis and Liver Injury in a Mouse Model of Non-alcoholic Steatohepatitis.

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Abstract

Non-alcoholic fatty liver disease is a major cause of liver-related morbidity and mortality. Metformin is a widely used medication and may have additional benefits beyond glycemic control. Liraglutide, a novel treatment for diabetes and obesity, also has beneficial effects on non-alcoholic steatohepatitis (NASH). Metformin and liraglutide have both benefited NASH treatment. However, no study has reported the effects of combination therapy with liraglutide and metformin on NASH.

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Journal ID (iso-abbrev): In Vivo

Title: In vivo (Athens, Greece)

Publisher: Anticancer Research USA Inc.

ISSN (Electronic): 1791-7549

ISSN (Print): 0258-851X

Publication date (Electronic): 2023

Volume: 37

Issue: 3

Affiliations

[1 ] Department of Pharmacy, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, R.O.C.

[2 ] Graduate Institute of Clinical Pharmacy, College of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.

[3 ] Holistic Education Center, Tzu Chi University of Science and Technology, Hualien, Taiwan, R.O.C.

[4 ] Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.

[5 ] School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.

[6 ] China Medical University Children's Hospital, Taichung, Taiwan, R.O.C.

[7 ] Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan, R.O.C.

[8 ] Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.

[9 ] Laboratory Animal Service Center, China Medical University, Taichung, Taiwan, R.O.C.

[10 ] Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.; jaisingyang@gmail.com.

[11 ] Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.; chiou70202@gmail.com.

[12 ] Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.

Article

Publisher Item ID: 37/3/1037

DOI: 10.21873/invivo.13178

PMC ID: 10188031

PubMed ID: 37103096

SO-VID: b97db640-a01f-4140-b686-31fd3505f4c5

History

Keywords: liver injury,MCD diet,Liraglutide,non-alcoholic steatohepatitis,C57BL/6JNarl mouse model,metformin

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Keywords: liver injury, MCD diet, Liraglutide, non-alcoholic steatohepatitis, C57BL/6JNarl mouse model, metformin

Liraglutide With Metformin Therapy Ameliorates Hepatic Steatosis and Liver Injury in a Mouse Model of Non-alcoholic Steatohepatitis.

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Neuropharmacology and Therapy

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