Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial.

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Abstract

The intestinal microbiota is implicated in the pathogenesis of ulcerative colitis. Faecal microbiota transplantation is a novel form of therapeutic microbial manipulation, but its efficacy in ulcerative colitis is uncertain. We aimed to establish the efficacy of intensive-dosing, multidonor, faecal microbiota transplantation in active ulcerative colitis.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Mar 25 2017

Volume: 389

Issue: 10075

Affiliations

[1 ] St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia; Department of Gastroenterology, St Vincent's Hospital, Sydney, NSW, Australia; Department of Gastroenterology, Nambour General Hospital, Nambour, QLD, Australia; Department of Gastroenterology, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia.

[2 ] Departments of Gastroenterology and Medicine, St Vincent's Hospital and University of Melbourne, Melbourne, VIC, Australia. Electronic address: mkamm@unimelb.edu.au.

[3 ] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

[4 ] Department of Gastroenterology, St Vincent's Hospital, Sydney, NSW, Australia.

[5 ] Department of Gastroenterology, Nambour General Hospital, Nambour, QLD, Australia.

[6 ] Department of Gastroenterology, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia.

[7 ] South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia; Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia; Ingham Institute, Sydney, NSW, Australia.

[8 ] South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia; Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia.

[9 ] Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia.

[10 ] South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia; Ingham Institute, Sydney, NSW, Australia.

[11 ] Centre for Digestive Diseases, Sydney, NSW, Australia.

[12 ] School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.

Article

Publisher Item ID: S0140-6736(17)30182-4

DOI: 10.1016/S0140-6736(17)30182-4

PubMed ID: 28214091

SO-VID: ede4db45-e9fa-48b8-8896-c6141aa9f789

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