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Abstract
The intraplantar injection of Bothrops jararaca venom (Bjv) caused an edematogenic
response in the rat which was of rapid onset, and reached a peak in about 60 min.
The response was markedly attenuated in animals rendered leucopenic by the administration
of amethopterin. This inhibition was partially reverted when leucopenic rats were
given i.v. suspensions of lymphocytes. Suspensions of neutrophils were ineffective.
If the animals were submitted to an experimental obstruction of the thoracic duct,
which leads to specific lymphocytopenia, similar inhibition of the edematogenic response
was observed. These results suggest that lymphocytes can directly influence the development
of the edema induced by Bothrops jararaca venom.