Regulation of neuroinflammation in Alzheimer&apos;s disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Alzheimer's disease (AD) is characterized by neuroinflammation linked to amyloid β (Aβ) aggregation and phosphorylated tau (τ) protein in neurofibrillary tangles (NFTs). Key elements in Aβ production and NFT assembly, like γ-secretase and p38 mitogen-activated protein kinase (p38MAPK), contribute to neuroinflammation. In addition, impaired proteosomal and autophagic pathways increase Aβ and τ aggregation, leading to neuronal damage. Conventional neuroinflammation drugs have limitations due to unidirectional therapeutic approaches and challenges in crossing the Blood-Brain Barrier (BBB). Clinical trials for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutics remain uncertain. Novel strategies addressing the complex pathogenesis and BBB translocation are needed to effectively tackle AD-related neuroinflammation.

Related collections

Most cited references 265

Record: found
Abstract: found
Article: found

Is Open Access

Open Babel: An open chemical toolbox

Noel O’Boyle, Michael Banck, Craig James … (2011)

Background A frequent problem in computational modeling is the interconversion of chemical structures between different formats. While standard interchange formats exist (for example, Chemical Markup Language) and de facto standards have arisen (for example, SMILES format), the need to interconvert formats is a continuing problem due to the multitude of different application areas for chemistry data, differences in the data stored by different formats (0D versus 3D, for example), and competition between software along with a lack of vendor-neutral formats. Results We discuss, for the first time, Open Babel, an open-source chemical toolbox that speaks the many languages of chemical data. Open Babel version 2.3 interconverts over 110 formats. The need to represent such a wide variety of chemical and molecular data requires a library that implements a wide range of cheminformatics algorithms, from partial charge assignment and aromaticity detection, to bond order perception and canonicalization. We detail the implementation of Open Babel, describe key advances in the 2.3 release, and outline a variety of uses both in terms of software products and scientific research, including applications far beyond simple format interconversion. Conclusions Open Babel presents a solution to the proliferation of multiple chemical file formats. In addition, it provides a variety of useful utilities from conformer searching and 2D depiction, to filtering, batch conversion, and substructure and similarity searching. For developers, it can be used as a programming library to handle chemical data in areas such as organic chemistry, drug design, materials science, and computational chemistry. It is freely available under an open-source license from http://openbabel.org.

0 comments Cited 1714 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell, Margaret M. Billingsley, Rebecca M. Haley … (2020)

In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental and cellular — that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

0 comments Cited 1510 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng, Paul Edison (2021)

Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated to contribute 60-70% of all cases of dementia worldwide. According to the prevailing amyloid cascade hypothesis, amyloid-β (Aβ) deposition in the brain is the initiating event in AD, although evidence is accumulating that this hypothesis is insufficient to explain many aspects of AD pathogenesis. The discovery of increased levels of inflammatory markers in patients with AD and the identification of AD risk genes associated with innate immune functions suggest that neuroinflammation has a prominent role in the pathogenesis of AD. In this Review, we discuss the interrelationships between neuroinflammation and amyloid and tau pathologies as well as the effect of neuroinflammation on the disease trajectory in AD. We specifically focus on microglia as major players in neuroinflammation and discuss the spatial and temporal variations in microglial phenotypes that are observed under different conditions. We also consider how these cells could be modulated as a therapeutic strategy for AD.

0 comments Cited 806 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (iso-abbrev): Phytomedicine

Title: Phytomedicine : international journal of phytotherapy and phytopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1618-095X

ISSN (Print): 0944-7113

Publication date (Electronic): Jan 2024

Volume: 122

Affiliations

[1 ] ICAR- National Institute on Foot and Mouth Disease-International Centre for Foot and Mouth Disease, Arugul, Bhubaneswar, Odisha (752050), India.

[2 ] Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra (410210), India.

[3 ] Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar, Odisha (751004), India.

[4 ] Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (02115), United States of America.

[5 ] Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh (221005), India.

[6 ] School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar 751024, India.

[7 ] Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh (221005), India.

[8 ] Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu (8080196), Japan.

[9 ] Department of Biotechnology, Faculty of Science, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh 484887, India.

[10 ] Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu (8080196), Japan. Electronic address: krbs09@gmail.com.

[11 ] Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar, Odisha (751004), India. Electronic address: routgeorgekerry3@gmail.com.

Article

Publisher Item ID: S0944-7113(23)00509-3

DOI: 10.1016/j.phymed.2023.155150

PubMed ID: 37944239

SO-VID: c75cc74d-e4a1-43be-9565-51783ffc2b96

History

Keywords: Neuroinflammation,Tau protein,Phytocompounds,Neurofibrillary tangles,Nanotherapeutics,Autophagy,Amyloid β

Data availability:

Keywords: Neuroinflammation, Tau protein, Phytocompounds, Neurofibrillary tangles, Nanotherapeutics, Autophagy, Amyloid β

Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties.

Read this article at

Abstract

Related collections

Biomarkers for Inflammatory Lung Disease

Most cited references 265

Open Babel: An open chemical toolbox

Engineering precision nanoparticles for drug delivery

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 312

Cited by 2

Most referenced authors 3,903