Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages.

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Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) may have extra-hepatic effects on cholesterol homeostasis of vascular macrophages. In this study, we aimed to investigate PCSK9 role on the anti-atherogenic process of ATP binding cassette transporter A1 (Abca1)-mediated cholesterol efflux.

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Author and article information

Journal

Journal ID (iso-abbrev): Atherosclerosis

Title: Atherosclerosis

Publisher: Elsevier BV

ISSN (Electronic): 1879-1484

ISSN (Print): 0021-9150

Publication date (Electronic): Jan 2017

Volume: 256

Affiliations

[1 ] Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, Parma, Italy.

[2 ] Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, Parma, Italy. Electronic address: ilaria.zanotti@unipr.it.

[3 ] Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.

[4 ] Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Padova, Italy.

Article

Publisher Item ID: S0021-9150(16)31487-3

DOI: 10.1016/j.atherosclerosis.2016.11.019

PubMed ID: 27940374

SO-VID: a15264bc-e06f-4bf5-a234-7e3165d70f02

History

Keywords: PCSK9,Macrophage,Cholesterol efflux,ABCA1

Data availability:

Keywords: PCSK9, Macrophage, Cholesterol efflux, ABCA1

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