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      Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality

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          Abstract

          Keratoconus provides a decrease of quality of life to the patients who suffer from it. The treatment used as well as the method to correct the refractive error of these patients may influence on the impact of the disease on their quality of life. The purpose of this review is to describe the evidence about the conservative surgical treatment for keratoconus aiming to therapeutic and refractive effect. The visual rehabilitation for keratoconic corneas requires addressing three concerns: halting the ectatic process, improving corneal shape, and minimizing the residual refractive error. Cross-linking can halt the disease progression, intrastromal corneal ring segments can improve the corneal shape and hence the visual quality and reduce the refractive error, PRK can correct mild-moderate refractive error, and intraocular lenses can correct from low to high refractive error associated with keratoconus. Any of these surgical options can be performed alone or combined with the other techniques depending on what the case requires. Although it could be considered that the surgical option for the refracto-therapeutic treatment of the keratoconus is a reality, controlled, randomized studies with larger cohorts and longer follow-up periods are needed to determine which refractive procedure and/or sequence are most suitable for each case.

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          Most cited references131

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          Global consensus on keratoconus and ectatic diseases.

          Despite extensive knowledge regarding the diagnosis and management of keratoconus and ectatic corneal diseases, many controversies still exist. For that reason, there is a need for current guidelines for the diagnosis and management of these conditions. This project aimed to reach consensus of ophthalmology experts from around the world regarding keratoconus and ectatic diseases, focusing on their definition, concepts, clinical management, and surgical treatments. The Delphi method was followed with 3 questionnaire rounds and was complemented with a face-to-face meeting. Thirty-six panelists were involved and allocated to 1 of 3 panels: definition/diagnosis, nonsurgical management, or surgical treatment. The level of agreement considered for consensus was two thirds. Numerous agreements were generated in definitions, methods of diagnosing, and management of keratoconus and other ectatic diseases. Nonsurgical and surgical treatments for these conditions, including the use of corneal cross-linking and corneal transplantations, were presented in a stepwise approach. A flowchart describing a logical management sequence for keratoconus was created. This project resulted in definitions, statements, and recommendations for the diagnosis and management of keratoconus and other ectatic diseases. It also provides an insight into the current worldwide treatment of these conditions.
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            Riboflavin/ultraviolet-a–induced collagen crosslinking for the treatment of keratoconus

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              Keratoconus and related noninflammatory corneal thinning disorders

              Keratoconus and other noninflammatory corneal thinning disorders (keratoglobus, pellucid marginal degeneration and posterior keratoconus) are characterized by progressive corneal thinning, protrusion and scarring; the result is distorted and decreased vision. The etiology and pathogenesis of these disorders are unknown but may be associated with a variety of factors, including contact lens wear, eye rubbing, Down's syndrome, atopic disease, connective tissue disease, tapetoretinal degeneration and inheritance. Recent advances in techniques for biochemical and pathological investigation are now allowing further exploration in these areas. Early diagnosis is aided by the finding of irregular corneal astigmatism with inferior corneal steepening. Treatment ranges from simple spectacle correction to keratoplasty. In this review, the past and present literature on corneal thinning disorders is reviewed and practical approaches to diagnosis and management are outlined.
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                Author and article information

                Contributors
                Journal
                J Ophthalmol
                J Ophthalmol
                JOPH
                Journal of Ophthalmology
                Hindawi
                2090-004X
                2090-0058
                2017
                18 December 2017
                : 2017
                : 7589816
                Affiliations
                1Fernández-Vega Ophthalmological Institute, Oviedo, Spain
                2Department of Corneal and External Eye Diseases, The Royal Liverpool University Hospital, Liverpool, UK
                3Instituto Zaldivar, Mendoza, Argentina
                4Department of Corneal Disease, Instituto Zaldivar, Mendoza, Argentina
                5Moorfields Eye Hospital, London, UK
                6Optics II Department, Optics and Optometry Faculty, Complutense University of Madrid, Madrid, Spain
                Author notes

                Academic Editor: Edward Manche

                Author information
                http://orcid.org/0000-0001-9197-5847
                http://orcid.org/0000-0002-5148-7643
                http://orcid.org/0000-0002-9390-4433
                http://orcid.org/0000-0002-0373-8209
                Article
                10.1155/2017/7589816
                5748308
                6e8d91c0-fdb5-4c0c-b5aa-ce782ce7c739
                Copyright © 2017 L. Fernández-Vega-Cueto et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 19 September 2017
                : 28 November 2017
                Categories
                Review Article

                Ophthalmology & Optometry
                Ophthalmology & Optometry

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