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      The Relationship between Uric Acid/Albumin Ratio and Carotid Intima-Media Thickness in Patients with Hypertension.

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          Abstract

          Hypertension causes subendothelial inflammation and dysfunction in resulting atherosclerosis. Carotid intima-media thickness (CIMT) is a useful marker of endothelial dysfunction and atherosclerosis. The uric acid to albumin ratio (UAR) has emerged as a novel marker for predicting cardiovascular events.

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          Most cited references40

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          2018 ESC/ESH Guidelines for the management of arterial hypertension

          Bryan P. Williams, Giuseppe Mancia, Wilko Spiering … (2018)
          Article 0 comments Cited 2779 times – based on 0 reviews     Review now
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            Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.

            Michael J. Pencina, Ralph B. D' Agostino, Ramachandran S. Vasan (2008)
            Identification of key factors associated with the risk of developing cardiovascular disease and quantification of this risk using multivariable prediction algorithms are among the major advances made in preventive cardiology and cardiovascular epidemiology in the 20th century. The ongoing discovery of new risk markers by scientists presents opportunities and challenges for statisticians and clinicians to evaluate these biomarkers and to develop new risk formulations that incorporate them. One of the key questions is how best to assess and quantify the improvement in risk prediction offered by these new models. Demonstration of a statistically significant association of a new biomarker with cardiovascular risk is not enough. Some researchers have advanced that the improvement in the area under the receiver-operating-characteristic curve (AUC) should be the main criterion, whereas others argue that better measures of performance of prediction models are needed. In this paper, we address this question by introducing two new measures, one based on integrated sensitivity and specificity and the other on reclassification tables. These new measures offer incremental information over the AUC. We discuss the properties of these new measures and contrast them with the AUC. We also develop simple asymptotic tests of significance. We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers.
            Article 0 comments Cited 789 times – based on 0 reviews     Review now
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              Evaluating the yield of medical tests.

              F Harrell, R M Califf, D Pryor … (1982)
              A method is presented for evaluating the amount of information a medical test provides about individual patients. Emphasis is placed on the role of a test in the evaluation of patients with a chronic disease. In this context, the yield of a test is best interpreted by analyzing the prognostic information it furnishes. Information from the history, physical examination, and routine procedures should be used in assessing the yield of a new test. As an example, the method is applied to the use of the treadmill exercise test in evaluating the prognosis of patients with suspected coronary artery disease. The treadmill test is shown to provide surprisingly little prognostic information beyond that obtained from basic clinical measurements.
              Article 0 comments Cited 375 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Arq Bras Cardiol
                Title: Arquivos brasileiros de cardiologia
                Publisher: Sociedade Brasileira de Cardiologia
                ISSN (Electronic): 1678-4170
                ISSN (Print): 0066-782X
                Publication date (Electronic): Mar 2023
                Volume: 120
                Issue: 5
                Affiliations
                [1 ] Departamento de Cardiologia, Universidade de Ciências da Saúde, Van Training and Education Hospital, Van - Turquia.
                [2 ] Departamento de Cardiologia, Universidade de Ciências da Saúde, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul - Turquia.
                [3 ] Departamento de Cardiologia e Bioestatística, Istanbul Nisantasi University, Istanbul - Turquia.
                Article
                Publisher Item ID: S0066-782X2023000500302
                DOI: 10.36660/abc.20220819
                PMC ID: 10124582
                PubMed ID: 37098960
                SO-VID: a4f2fa89-5c40-4532-a775-fd5a203aa183
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